Recombinant BMP-7 (Bone morpho

gene_symbol
Description：Recombinant BMP-7 (Bone morphogenetic protein-7)，Human
Accn
Unipro ID：P18075
Synonyms：Osteogenic Protein-1 (OP-1)
Species：Human
Amount：20 ug
Delivery time：2周
Expression sequence：MANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH with polyhistidine tag at the C-terminus.
Tags：His Tag (C-term)
PredictedMW：The protein has a calculated MW of 14.00 kDa. The protein migrates as 12 kDa under reducing condition (SDS-PAGE analysis).
Buffer：The protein was lyophilized from a 0.2 µm filtered solution containing 20 mM sodium citrate, 0.2 M NaCl, pH 3.5.
Stability
Bioactivity：Measure by its ability to induce alkaline phosphatase production by ATDC5 cells. The ED₅₀ for this effect is <0.65 μg/mL.
Purity：>95% as determined by SDS-PAGE.
Concentration
Preparation
Endotoxin：<0.1 EU per 1 μg of the protein by the LAL method.
Shipping
Background：Bone Morphogenetic Protein-7 (BMP-7) is an extracellular multifunctional cytokine that is also a member of the TGF-β family. BMP7 can significantly inhibit TGF-β through binding with TGF-β receptor and trigger SMAD transcription factors, such as SMAD 1 /5/8. It plays a vital role in inhibiting the expansion of kidney damage and promoting the differentiation of osteoblasts.