Purified recombinant protein o

gene_symbol：MSH6
Description：Purified recombinant protein of Human mutS homolog 6 (E. coli) (MSH6),Met1-Ser280, with N-terminal His tag, expressed in E. coli, 50ug
Accn：NM_000179
Unipro ID：P52701
Synonyms：GTBP; GTMBP; HNPCC5; HSAP; MMRCS3; p160
Species：Human
Amount：50 ug
Delivery time：现货
Expression sequence：A DNA sequence encoding the region(Met1-Ser280) of MSH6
Tags：N-His
PredictedMW：30.7 kDa
Buffer：50 mM Tris-HCl, pH 8.0, 8 M urea
Stability：Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Bioactivity
Purity：> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration：>0.05 µg/µL as determined by microplate BCA method
Preparation
Endotoxin
Shipping
Background：This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]