Plasminogen / PLG human protei

gene_symbol：PLG
Description：Plasminogen / PLG human protein, 1 mg
Accn：NM_000301
Unipro ID
Synonyms：HAE4
Species：Human
Amount：1 mg
Delivery time：7周
Expression sequence
Tags
PredictedMW
Buffer：Presentation State: PurifiedState: Lyophilized purified fractionBuffer System: 20 mM Tris, pH 7.5, containing 2 mM EDTAPreservative: None
Stability：Shelf life: one year from despatch.
Bioactivity：Specific: Activity : ≥ 120 units per mg protein. One unit is defined as the amount of enzyme, which will hydrolyze 1 µmole of N-tosyl-L-arginine ester in 30 minutes at 37°C at pH 8.0.
Purity：>95% pure by SDS-PAGE
Concentration：lot specific
Preparation：Lyophilized purified fraction
Endotoxin
Shipping
Background：The plasminogen protein encoded by this gene is a serine protease that circulates in blood plasma as an inactive zymogen and is converted to the active protease, plasmin, by several plasminogen activators such as tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), kallikrein, and factor XII (Hageman factor). The conversion of plasminogen to plasmin involves the cleavage of the peptide bond between Arg-561 and Val-562. Plasmin cleavage also releases the angiostatin protein which inhibits angiogenesis. Plasmin degrades many blood plasma proteins, including fibrin-containing blood clots. As a serine protease, plasmin cleaves many products in addition to fibrin such as fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin is inactivated by proteins such as alpha-2-macroglobulin and alpha-2-antiplasmin in addition to inhibitors of the various plasminogen activators. Plasminogen also interacts with plasminogen receptors which results in the retention of plasmin on cell surfaces and in plasmin-induced cell signaling. The localization of plasminogen on cell surfaces plays a role in the degradation of extracellular matrices, cell migration, inflamation, wound healing, oncogenesis, metastasis, myogenesis, muscle regeneration, neurite outgrowth, and fibrinolysis. This protein may also play a role in acute respiratory distress syndrome (ARDS) which, in part, is caused by enhanced clot formation and the suppression of fibrinolysis. Compared to other mammals, the cluster of plasminogen-like genes to which this gene belongs has been rearranged in catarrhine primates. [provided by RefSeq, May 2020]