Purified recombinant protein o

gene_symbol：ABL1
Description：Purified recombinant protein of Human c-abl oncogene 1, non-receptor tyrosine kinase (ABL1), transcript variant b,Arg893-Lys966, with N-terminal His-ABP tag, expressed in E. coli, 50ug
Accn：NM_007313
Unipro ID：P00519
Synonyms：ABL; BCR-ABL; bcr/abl; c-ABL; c-ABL1; CHDSKM; JTK7; p150; v-abl
Species：Human
Amount：50 ug
Delivery time：4周
Expression sequence：A DNA sequence encoding the region(Arg893-Lys966)of ABL1
Tags：N-His-ABP (Albumin-Binding Protein)
PredictedMW：22.4 kDa
Buffer：25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 10% glycerol
Stability：Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Bioactivity
Purity：> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration：>0.05 µg/µL as determined by microplate BCA method
Preparation
Endotoxin
Shipping
Background：This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]