Purified recombinant protein o

gene_symbol：Collagen I
Description：Purified recombinant protein of Human collagen, type I, alpha 1 (COL1A1), with N-terminal His tag, secretory expressed in HEK293 cells, 50ug
Accn：NM_000088
Unipro ID：P02452
Synonyms：CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4
Species：Human
Amount：50 ug
Delivery time：2周
Expression sequence：A DNA sequence from TrueORF clone, [RC206234], encoding the region Gln300-Asp744 of COL1A1
Tags：N-His
PredictedMW：40.8 kDa
Buffer：PBS, pH 7.4, 10% glycerol
Stability：Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Bioactivity
Purity：> 90% as determined by SDS-PAGE and Coomassie blue staining
Concentration：>0.05 µg/µL as determined by microplate BCA method
Preparation
Endotoxin
Shipping
Background：This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]