Purified recombinant protein o

gene_symbol：PATZ1
Description：Purified recombinant protein of Human POZ (BTB) and AT hook containing zinc finger 1 (PATZ1), transcript variant 1, full length, with N-terminal HIS tag, expressed in E. coli, 50ug
Accn：NM_014323
Unipro ID：Q9HBE1
Synonyms：dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; ZSG
Species：Human
Amount：50 ug
Delivery time：2周
Expression sequence：A DNA sequence encoding human full-length PATZ1
Tags：N-His
PredictedMW：73.9 kDa
Buffer：25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Stability：Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Bioactivity
Purity：> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration：>0.05 µg/µL as determined by microplate BCA method
Preparation
Endotoxin
Shipping
Background：The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]