Recombinant protein of human c

gene_symbol：Cyclin D1
Description：Recombinant protein of human cyclin D1(CCND1),full length,with C-terminal flag tag,expressed in sf9 cells
Accn：NM_053056
Unipro ID：P24385
Synonyms：BCL1; D11S287E; PRAD1; U21B31
Species：Human
Amount：20 ug
Delivery time：现货
Expression sequence：A DNA sequence from TrueORF clone, [RC204957], encoding human full-length CCND1
Tags：C-DDK
PredictedMW：34 kDa
Buffer：50 mM Tris-HCl, pH 8.0, 150 mM NaCl, 10% glycerol
Stability：Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Bioactivity
Purity：> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration：>0.05 µg/µL as determined by microplate BCA method
Preparation
Endotoxin
Shipping
Background：The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]