Recombinant protein of human a

gene_symbol：ALK
Description：Recombinant protein of human anaplastic lymphoma receptor tyrosine kinase (ALK),residues residues 1060-1620, with N-terminal polyhistidine tag, expressed in sf9 cells.
Accn：NM_004304
Unipro ID：Q9UM73
Synonyms：CD246; NBLST3
Species：Human
Amount：20 ug
Delivery time：现货
Expression sequence：A DNA sequence from TrueORF clone, [RC222485], encoding the region (Arg1060-Pro1620) of human ALK
Tags：N-His
PredictedMW：62 kDa
Buffer：50 mM Tris-HCl, pH 8.0, 150 mM NaCl, 10% glycerol
Stability：Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Bioactivity
Purity：> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration：>0.05 µg/µL as determined by microplate BCA method
Preparation
Endotoxin
Shipping
Background：This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]