Purified recombinant protein o

gene_symbol：CTCF
Description：Purified recombinant protein of Human CCCTC-binding factor (zinc finger protein) (CTCF), transcript variant 1
Accn：NM_006565
Unipro ID：P49711
Synonyms：CFAP108; FAP108; MRD21
Species：Human
Amount：10 ug
Delivery time：2周
Expression sequence：Met1-Ile154
Tags：Tag Free
PredictedMW：16.9 kDa
Buffer：Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Stability：Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Bioactivity：EMSA reaction positive control (PMID: 29666371)
Purity：>95% as determined by SDS-PAGE and Coomassie blue staining
Concentration：lot specific
Preparation
Endotoxin：Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Shipping
Background：This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]