PTEN Rabbit polyclonal Antibod

gene_symbol：PTEN
predicted_size：19kDa/47kDa/64kDa
Uniprot ID：P6484
description：PTEN Rabbit polyclonal Antibody
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
immunogen：Recombinant fusion protein containing a sequence corresponding to amino acids 209-403 of human PTEN (NP_000305.3).
recommended_dilution：WB,1:500 - 1:2000 IHC,1:50 - 1:200 IF,1:50 - 1:200
predicted_size：19kDa/47kDa/64kDa
buffer：Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
host_species：Rabbit
applications：IF, IHC, WB
reactivities：Human, Mouse, Rat