HMGCR Rabbit polyclonal Antibo

gene_symbol：HMGCR
predicted_size：92kDa/97kDa/99kDa
Uniprot ID：P435
description：HMGCR Rabbit polyclonal Antibody
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
immunogen：Recombinant protein of human HMGCR.
recommended_dilution：WB,1:500 - 1:2000 IHC,1:50 - 1:100 IF,1:50 - 1:100
predicted_size：92kDa/97kDa/99kDa
buffer：Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
host_species：Rabbit
applications：IF, IHC, WB
reactivities：Human, Mouse, Rat