Cyclin D1 Rabbit polyclonal An

gene_symbol：CCND1
predicted_size：33kDa
Uniprot ID：P24385
description：Cyclin D1 Rabbit polyclonal Antibody
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
immunogen：A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human Cyclin D1 (NP_444284.1).
recommended_dilution：WB,1:500 - 1:2000 IHC,1:50 - 1:200 IF,1:50 - 1:200 IP,1:50 - 1:100
predicted_size：33kDa
buffer：Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
host_species：Rabbit
applications：IF, IHC, IP, WB
reactivities：Human, Mouse, Rat