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- 详细信息
- 文献和实验
- 技术资料
- 品系：
详见细胞说明资料
- 细胞类型：
详见细胞说明资料
- 肿瘤类型：
详见细胞说明资料
- 供应商：
上海冠导生物工程有限公司
- 库存：
≥100瓶
- 生长状态：
详见细胞说明资料
- 年限：
详见细胞说明资料
- 运输方式：
常温运输【复苏细胞】或干冰运输【冻存细胞】
- 器官来源：
详见细胞说明资料
- 是否是肿瘤细胞：
详见细胞说明资料
- 细胞形态：
详见细胞说明资料
- 免疫类型：
详见细胞说明资料
- 物种来源：
详见细胞说明资料
- 相关疾病：
详见细胞说明资料
- 组织来源：
详见细胞说明资料
- 英文名：
786-O[786-0]人肾透明细胞腺癌传代细胞长期复苏|送STR图谱
- 规格：
1*10(6)Cellls/瓶
"786-O[786-0]人肾透明细胞腺癌传代细胞长期复苏|送STR图谱
传代方法：1:2-1:4(首次传代建议1:2)
生长特性：贴壁生长
换液频率：每周2-3次
背景资料：该细胞源自一位原发性肾透明细胞癌患者。该细胞有微绒毛和桥粒，能在软琼脂上生长。此细胞生成一种PTH（甲状旁腺素）样的多肽，与乳癌和肺癌中生成的肽相似，其N端序列与PTH相似，具有PTH样活性，分子量为６０００D。
活细胞：通常具有透亮的外观、完整的细胞膜，以及清晰可见的细胞核和细胞质内的细胞器。对于贴壁细胞，活细胞能够牢固地贴附在培养皿或培养瓶上。死细胞：则呈现暗淡无光、细胞膜可能碎裂的状态，且无法有效贴壁(对于贴壁细胞而言)。悬浮细胞死细胞则可能表现出膜碎裂、内容物外泄等现象。不同类型的细胞具有特定的生长形态，如成纤维型细胞呈细长形状并附着在基质上生长，上皮型细胞呈多边形等。观察细胞是否保持其特有的生长形态也是判断细胞状态的重要依据。细胞培养员应及时记录细胞培养过程中的关键数据，包括细胞形态、染色结果、生长速度等。建立完善的数据记录系统，有助于追踪细胞状态的变化，并为后续分析提供依据。
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GM01766 Cells(拥有STR基因鉴定图谱)
COLO 699 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：TE671/RD Cells、UCD-MLA-144 Cells、ZR-75-30 Cells
HT-115 Cells;背景说明：结肠癌;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：32D.3 Cells、HSMC Cells、A-172 MG Cells
786-O[786-0]人肾透明细胞腺癌传代细胞长期复苏|送STR图谱
产品包装形式：复苏细胞：T25培养瓶(一瓶)或冻存细胞：1ml冻存管(两支)
来源说明：细胞主要来源ATCC、DSMZ等细胞库
传代的操作步骤注意事项：1)操作前要洗手，进入超净台后手要用75%酒精或0.2%擦试。试剂等瓶口也要擦试。2)点燃酒精灯，操作在火焰附近进行，耐热物品要经常在火焰上烧灼，金属器械烧灼时间不能太长，以免退火，并冷却后才能夹取组织，吸取过营养的用具不能再烧灼，以免烧焦形成碳膜。3)操作动作要准确敏捷，但又不能太快，以防空气流动，增加污染机会。4)不能用手触已消毒器皿的工作部分，工作台面上用品要布局合理。5)瓶子开口后要尽量保持45℃斜位。6)吸溶的吸管等不能混用。贴壁细胞传代的操作步骤：1)吸除培养瓶内旧培养。2)向瓶内加入胰蛋白酶和EDA混合少许，以能覆满瓶底为限。3)置温箱中2-5分钟，当发现细胞质回缩，细胞间隙增大后，立即终止消化。4)吸除消化，向瓶内注入Hanks数毫升，轻轻转动培养瓶，把残余消化冲掉。注意加Hanks冲洗细胞时，动作要轻，以免把已松动的细胞冲掉流失，如用胰蛋白酶单独消化，吸除胰蛋白酶后，可不用Hanks冲洗，直接加入培养。5)用吸管吸取营养轻轻反复吹打瓶壁细胞，使之从瓶壁脱离形成细胞悬。6)计数板计数后，把细胞悬分成等份分装入数个培养瓶中，置温箱中培养。悬浮细胞传代的操作步骤：1)吸出细胞培养，放入离心管中，离心1000rpm5分钟。2)吸掉上清，加入适量之新鲜培养基，混和均匀后，依稀释比例转移至新的培养瓶中，以正常培养条件培养。
物种来源：Human\Mouse\Rat\Others
TE13 Cells;背景说明：食管鳞癌；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：H1944 Cells、GM05372 Cells、CT26.CL25 Cells
KM933 Cells;背景说明：B淋巴；EBV转化;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：悬浮;形态特性：详见产品说明;相关产品有：Psi-2 DAP Cells、SK-Mel1 Cells、BT549 Cells
ES-2 Cells;背景说明：ES-２细胞系源于一位４７岁黑人女性的临床卵巢透明细胞癌手术标本。该细胞对中低剂量的阿霉素，顺铂，双乙基亚硝脲，表鬼臼毒素吡喃葡糖苷等化疗药物有一定耐药性。该细胞少量表达糖蛋白P。;传代方法：１：３传代，２-３天传一次;生长特性：贴壁生长;形态特性：上皮样;相关产品有：OCI/AML-2 Cells、GMK,BSC-1 Cells、TOV-112 Cells
786-O[786-0]人肾透明细胞腺癌传代细胞长期复苏|送STR图谱
形态特性：上皮细胞样
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ATCC细胞库(American Type Culture Colection)，该中心一直致力于细胞分类、鉴定和保藏工作。ATCC是全球最大的生物资源保藏中心，ATCC通过行业标准产品、服务和创新解决方案支持全球学术、政府、生物技术、制药、食品、农业和工业领域的科学进步。ATCC提供的服务和定制解决方案包括细胞和微生物培养、鉴定、生物衍生物的开发和生产、性能测试和生物资源保藏服务。美国国家标准协会(ANSI)认可了ATCC标准开发组织，并制定了标准协议，以确保生物材料的可靠性和可重复性。ATCC的使命是为了获取、鉴定、保存、开发、标准化和分发生物资源和生物信息，以提高和应用生物科学知识。
HCC366 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：L-363 Cells、KYSE70 Cells、GM00637H Cells
A549 ATCC Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：ECC1 Cells、NCI-H2023 Cells、NCIH2122 Cells
MDA231-LM2 Cells;背景说明：乳腺癌;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：NCI H716 Cells、MA-782 Cells、Reuber H-35 Cells
HCCLM6 Cells;背景说明：肝癌;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：LM3 Cells、639 V Cells、Capan 2 Cells
H-146 Cells;背景说明：详见相关文献介绍;传代方法：１：２—１：６传代，每周换液２-３次;生长特性：悬浮生长;形态特性：上皮细胞;相关产品有：HCC-1359 Cells、H64 Cells、KALS1 Cells
SNUC1 Cells;背景说明：详见相关文献介绍;传代方法：每３-５天换液。;生长特性：悬浮生长;形态特性：上皮细胞;相关产品有：HSC3 Cells、PY8119 Cells、AML-EOL-1 Cells
PG13 Cells;背景说明：胚胎；成纤维 Cells;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：MNNG-HOS Cells、MDST8 Cells、FRTL-5 Cells
KYSE 520 Cells;背景说明：食管鳞癌；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：H2122 Cells、RC-4B/C Cells、NCIH889 Cells
LAPC4 Cells;背景说明：前列腺癌；淋巴结转移；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：EVSAT Cells、SNU886 Cells、Bovine ENDometrial cells Cells
HS688AT Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代;生长特性：贴壁生长;形态特性：成纤维细胞;相关产品有：OPM2 Cells、COV 504 Cells、Adeno 293 Cells
Centre Antoine Lacassagne-12T Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：MDA MB 134VI Cells、HOS Cells、Bronchial Epithelium transformed with Ad12-SV40 2B Cells
HeLa229 Cells;背景说明：宫颈癌；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：RT-BM-1 Cells、CA-46 Cells、OCI-Ly 7 Cells
Neuro 2a Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：４传代；２-３天换液１次;生长特性：贴壁生长;形态特性：详见产品说明;相关产品有：A10 Cells、HCC-95 Cells、OLN 93 Cells
MCA-205 Cells;背景说明：纤维肉瘤;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：HEK-293 c18 Cells、NCI-SNU-1040 Cells、Nb2a Cells
Murine Long bone Osteocyte-Y4 Cells;背景说明：骨；SV４０转化;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：SCC VII Cells、OCI/AML5 Cells、MONO-MAC 6 Cells
Y79 Cells;背景说明：１９７１年１月，该细胞由ReidTW及其同事从病人右眼切除的肿瘤进行原代培养建立而成，此病人有很强的视网膜母细胞瘤的母系家族遗传性。该细胞的超微结构，如核膜内折、三层膜结构、大的被膜小泡、环孔板、微管、中心粒、基粒等都与原始肿瘤相似。;传代方法：１：２传代;生长特性：悬浮生长;形态特性：圆形，成簇生长;相关产品有：CHL-1 Cells、MAVER Cells、NCI-H211 Cells
Calu6 Cells;背景说明：详见相关文献介绍;传代方法：消化２０分钟。１：２。５-６天长满。;生长特性：贴壁生长;形态特性：上皮细胞;相关产品有：Ra #1 Cells、RPMI8402 Cells、HEK-A Cells
Abcam HEK293T SDHD KO Cells(拥有STR基因鉴定图谱)
AG12657 Cells(拥有STR基因鉴定图谱)
BayGenomics ES cell line RRC013 Cells(拥有STR基因鉴定图谱)
BayGenomics ES cell line XE422 Cells(拥有STR基因鉴定图谱)
BY00348 Cells(拥有STR基因鉴定图谱)
CSCR19i-indCFANCA Cells(拥有STR基因鉴定图谱)
DA04470 Cells(拥有STR基因鉴定图谱)
DD0698 Cells(拥有STR基因鉴定图谱)
MESSA Dx5 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：８传代；每周２-３次。;生长特性：贴壁生长;形态特性：成纤维细胞样 ;相关产品有：PASMCS Cells、CCD19-Lu Cells、U251 Cells
NCI-H522 Cells;背景说明：详见相关文献介绍;传代方法：１：３-１：６传代；每周换液２-３次。;生长特性：贴壁生长;形态特性：上皮样;相关产品有：SJCRH30 Cells、RIN-m 14B Cells、H2170 Cells
786-O[786-0]人肾透明细胞腺癌传代细胞长期复苏|送STR图谱
CEMx721.174.T2 Cells;背景说明：详见相关文献介绍;传代方法：１：３—１：６传代，每周换液２—３次;生长特性：悬浮生长;形态特性：淋巴母细胞样;相关产品有：Tn5B1-4 Cells、TE-13 Cells、2BS Cells
L-cell Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：MC116 Cells、TW-039 Cells、NCI-H1755 Cells
CF PAC-1 Cells;背景说明：详见相关文献介绍;传代方法：１：３-１０传代；２-３天换液１次。;生长特性：贴壁生长;形态特性：上皮细胞;相关产品有：WSU-DLCL(2) Cells、NCI-H841 Cells、TE12 Cells
A-375.S2 Cells;背景说明：详见相关文献介绍;传代方法：１：２传代;生长特性：贴壁生长;形态特性：上皮样;相关产品有：LN-229 Cells、H35 Cells、HCT 15 Cells
ND7/23 Cells;背景说明：神经母细胞瘤;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：BA/F3 Cells、LN229 Cells、P3X63 Ag8 Cells
D-341Med Cells;背景说明：详见相关文献介绍;传代方法：每周换液２-３次。;生长特性：悬浮生长;形态特性：髓母细胞样;相关产品有：MT2 Cells、hTERT-HPNE Cells、RPMI #8226 Cells
3E9 [Mouse hybridoma against DHAV VP3] Cells(拥有STR基因鉴定图谱)
SUP-M2 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：SW1271 Cells、D283MED Cells、Baby Hamster Kidney-21 Cells
GI-1 Cells;背景说明：详见相关文献介绍;传代方法：１：２传代;生长特性：贴壁生长;形态特性：上皮样;相关产品有：SUDHL-10 Cells、SW-1088 Cells、National Medical Center-Glioma 1 Cells
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OVCA 433 Cells;背景说明：卵巢癌；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：Japanese Tissue Culture-28 Cells、HPAF-II Cells、H-1944 Cells
LNCaP-C4-2 Cells;背景说明：前列腺癌；左锁骨上淋巴结转移；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：C6 Cells、QGY Cells、HT29 Cells
hTERT-RPE Cells;背景说明：视网膜色素上皮；hTERT永生；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：NPA'87 Cells、MEG-01 Cells、Adeno-293 Cells
NHA Cells;背景说明：星形胶质 Cells;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：MPP-89 Cells、CNE Cells、NIE 115 Cells
NB9 Cells;背景说明：详见相关文献介绍;传代方法：１：１０ １：５０每２ - ３周；每周换液２-３次。;生长特性：贴壁生长;形态特性：成神经细胞;相关产品有：WM451 Cells、A-9 Cells、MPC11 Cells
HOS(TE85) Cells;背景说明：骨肉瘤；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：HAVSMC Cells、NCI-841 Cells、NCIH2347 Cells
GM10071 Cells(拥有STR基因鉴定图谱)
HAP1 C10orf32 (-) 2 Cells(拥有STR基因鉴定图谱)
HO1-N1 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁生长;形态特性：上皮样;相关产品有：SU-DHL-8 Cells、Dakiki Cells、YH-13 Cells
T-ALL1 Cells;背景说明：该细胞源于一名复发T-ALL（急性T淋巴细胞性白血病）的儿童的外周血；具有很强的细胞毒性，体内体外实验中都能破坏肿瘤细胞；IL-２可使细胞更好地生长；α/β TCR阳性，γ/δ TCR阴性；可产生IFNγ、TNF-α和GM-CSF。;传代方法：维持细胞密度在４×１０５-１×１０６ cells/ml之间，２-３天换液１次 ;生长特性：悬浮生长;形态特性：淋巴母细胞;相关产品有：RS(4;11) Cells、HFE-145 Cells、SKMel-5 Cells
PL12 Cells;背景说明：详见相关文献介绍;传代方法：１：２传代;生长特性：贴壁生长;形态特性：上皮样;相关产品有：16HBE140 Cells、PA-TU-8988S Cells、HIBEpiC Cells
MDAPCa-2b Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：４传代，２-３天换液１次。;生长特性：贴壁生长;形态特性：上皮细胞;相关产品有：TOV-112D Cells、U-373MG Cells、HS-683 Cells
EHEB Cells;背景说明：B细胞白血病；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：悬浮;形态特性：详见产品说明;相关产品有：KYSE-270 Cells、SK-N-DZ Cells、Rh30 Cells
KS-1 [Human glioblastoma] Cells;背景说明：详见相关文献介绍;传代方法：１：２传代;生长特性：贴壁生长;形态特性：成纤维细胞;相关产品有：BEL 7405 Cells、BC-021 Cells、TE-7 Cells
CHO Lec1 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：Caco-2/BBe Cells、Adult Retinal Pigment Epithelial cell line-19 Cells、A375S2 Cells
RCC10 RGB Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：HCC1187 Cells、HEC-1B Cells、Rat Skin 1 Cells
HG03493 Cells(拥有STR基因鉴定图谱)
IDG-HEK293T-CALHM4-V5-OE Cells(拥有STR基因鉴定图谱)
LP-2 Cells(拥有STR基因鉴定图谱)
NCI-H838 KRAS (G12V/+9n) Cells(拥有STR基因鉴定图谱)
PathHunter U2OS MCHR2 beta-arrestin Cells(拥有STR基因鉴定图谱)
TS/A-pc Cells(拥有STR基因鉴定图谱)
UKWi001-A Cells(拥有STR基因鉴定图谱)
HEV0041 Cells(拥有STR基因鉴定图谱)
H87 Cells;背景说明：NCI-N８７细胞表达表面糖蛋白癌胚抗原(CEA)和TAG７２,并且没有左旋多巴胺脱羧酶(DDC)活性。它们的血管活性的肠肽(VIP)受体活性极低并缺乏胃泌激素受体。它们表达蕈毒碱胆碱受体。没有证据表明存在N-myc,L-myc,myb和EGF受体基因的重组。这个细胞株表达的c-myc和c-erb-B２RNA水平与其它细胞株相当。以下基因不表达:N-myc,L-myc,c-cis,IGF-２,或胃泌激素释放肽。报道NCI-N８７细胞的植板率为４.３%。;传代方法：消化１５-２０分钟。１：２。４-５天长满。;生长特性：贴壁生长;形态特性：上皮细胞样;相关产品有：LNCaP-ATCC Cells、HEK293F Cells、RC-2 Cells
SW 780 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：Hs-695-T Cells、H82sclc Cells、H-1734 Cells
HANK Cells;背景说明：NK/T细胞淋巴瘤；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：悬浮;形态特性：详见产品说明;相关产品有：BJAB-1 Cells、HCT/FU Cells、SUP-B1 Cells
Sun Yat-sen university Ophtalmic center-Retinoblastoma 50 Cells;背景说明：视网膜母细胞瘤；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：悬浮;形态特性：详见产品说明;相关产品有：Hs822T Cells、SNU-449 Cells、U266 B1 Cells
HCT.116 Cells;背景说明：结肠腺癌；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：SO-Rb 50 Cells、P3-X63-Ag8-653 Cells、SHSY-5Y Cells
HCT.116 Cells;背景说明：结肠腺癌；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：SO-Rb 50 Cells、P3-X63-Ag8-653 Cells、SHSY-5Y Cells
HS-766-T Cells;背景说明：详见相关文献介绍;传代方法：１：２—１：８传代，每周换液２—３次;生长特性：贴壁生长;形态特性：上皮细胞;相关产品有：HuCCT-1 Cells、COLO 394 Cells、ONS-76 Cells
HBE Cells;背景说明：详见相关文献介绍;传代方法：１：２传代;生长特性：贴壁生长 ;形态特性：详见产品说明;相关产品有：NCI-446 Cells、RL Cells、mIMCD3 Cells
HEC-1-B Cells;背景说明：该细胞是H.Kuramoto１９６８年分离的HEC-１-A细胞亚株。不同於HEC-A-１的是：该亚株在培养第１３５天到１９０天之间表现出稳定的生长周期，且重现扁平，与亲本细胞系相比更具铺路石式样。此外主要染色体组是亲本细胞的两倍。;传代方法：１：３传代，２-３天换液一次;生长特性：贴壁生长;形态特性：上皮样;相关产品有：QBC939 Cells、BrCL15 Cells、KP-4 Cells
526 Cells;背景说明：黑色素瘤;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：SK-RC-52 Cells、LUDLU-1 Cells、H548 Cells
HCET Cells;背景说明：角膜上皮细胞；Ad-SV４０转化；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：NCI H295R Cells、FM88 Cells、EA.hy 926 Cells
HCT116 Cells;背景说明：结肠腺癌；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：Rat podocyte Cells、MKN 45 Cells、SK-N-BE(2)C Cells
SW-948 Cells;背景说明：详见相关文献介绍;传代方法：１：２—１：５传代，每周换液１-２次;生长特性：贴壁生长;形态特性：上皮细胞样;相关产品有：SW 1573 Cells、CL-34 Cells、SKG-3a Cells
786-O[786-0]人肾透明细胞腺癌传代细胞长期复苏|送STR图谱
H2081 Cells;背景说明：详见相关文献介绍;传代方法：随细胞的密度而增加;生长特性：悬浮生长;形态特性：聚团悬浮;相关产品有：hFOB Cells、NCI-H2171 Cells、CP70 Cells
Hs 888Lu Cells;背景说明：详见相关文献介绍;传代方法：１：２传代;生长特性：贴壁生长 ;形态特性：详见产品说明;相关产品有：Ramos 2G6 4C10 Cells、KP2 Cells、KYSE70 Cells
SBDS-iPS1 Cells(拥有STR基因鉴定图谱)
GM17346 Cells;背景说明：１９６７年，该细胞系KleinE和KleinG建系，源于一名１６岁患有Burkitt＇s淋巴瘤的黑人男性，beta-２-微球蛋白阴性，表达EBNA,VCA，sIg。该细胞携带EB病毒，是一个典型的B淋巴母细胞系，可用于白血病发病机制的研究。;传代方法：１：２传代;生长特性：悬浮生长;形态特性：淋巴母细胞样;相关产品有：A-375.S2 Cells、Line 697 Cells、NCIH2342 Cells
Tj-905 Cells;背景说明：胶质瘤;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：GH 3 Cells、COLO678 Cells、mousepodocyte Cells
SF539 Cells;背景说明：胶质瘤；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：K562 Cells、SJ-Rh 30 Cells、3T3NIH Cells
WM-266-mel Cells;背景说明：详见相关文献介绍;传代方法：１：２传代;生长特性：贴壁生长;形态特性：详见产品说明;相关产品有：H2066 Cells、SK-RC-39 Cells、SPC-A1 Cells
┈订┈购┈热┈线：1┈5┈8┈0┈0┈5┈7┈6┈8┈6┈7【微信同号】┈Q┈Q：3┈3┈0┈7┈2┈0┈4┈2┈7┈1；
MOLM-13 Cells;背景说明：急性髓系白血病；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：悬浮;形态特性：详见产品说明;相关产品有：NCI N87 Cells、Sol8 Cells、WEHI3B Cells
KASUMI1 Cells;背景说明：详见相关文献介绍;传代方法：１：２传代。３天内可长满。;生长特性：悬浮生长;形态特性：原粒细胞;相关产品有：9L Cells、Tca-8113 Cells、NCI-H295R Cells
Ramos-RA1 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：H-740 Cells、H2052_MM Cells、870 Cells
H-2141 Cells;背景说明：详见相关文献介绍;传代方法：３-４天换液１次。;生长特性：悬浮生长;形态特性：聚团悬浮;相关产品有：67NR Cells、TK10 Cells、bEND.3 Cells
EFM-19 Cells;背景说明：乳腺管癌；胸腔积液转移；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：SKMES Cells、RD-ES Cells、HT-115 Cells
RS411 Cells;背景说明：详见相关文献介绍;传代方法：每周２-３次;生长特性：悬浮生长;形态特性：成淋巴细胞;相关产品有：NT2-D1 Cells、SF-539 Cells、HCC2185 Cells
NALM 6 Cells;背景说明：急性B淋巴细胞白血病；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：悬浮;形态特性：详见产品说明;相关产品有：MDA-1386 Cells、OVCA 420 Cells、HUT-125 Cells
CCD-1112sk Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：Renal Carcinoma Cells、NCI-H102 Cells、SW954 Cells
Calu-6 Cells;背景说明：详见相关文献介绍;传代方法：消化２０分钟。１：２。５-６天长满。;生长特性：贴壁生长;形态特性：上皮细胞;相关产品有：RCK8 Cells、373MG Cells、MMAc-SF Cells
OVCAR-3 Cells;背景说明：该细胞１９８２年由T.C. Hamilton等建系，源自一位６０卵巢腺癌的腹水，是卵巢癌抗药性研究的模型。;传代方法：１：２—１：４传代，每周换液２—３次;生长特性：贴壁生长;形态特性：上皮细胞样;相关产品有：AN3-CA Cells、L-Wnt-3A Cells、KNS42 Cells
BayGenomics ES cell line CSJ039 Cells(拥有STR基因鉴定图谱)
BayGenomics ES cell line SYA283 Cells(拥有STR基因鉴定图谱)
CC 92 Cells(拥有STR基因鉴定图谱)
M-1 [Mouse kidney] Cells(拥有STR基因鉴定图谱)
RAW264.7 clone C5 Cells(拥有STR基因鉴定图谱)
RSC96 L-periaxin KO Cells(拥有STR基因鉴定图谱)
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Jain M., Nilsson R., Sharma S., Madhusudhan N., Kitami T., Souza A.L., Kafri R., Kirschner M.W., Clish C.B., Mootha V.K.
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.
Science 336:1040-1044(2012)
PubMed=22949125; DOI=10.1002/ijc.27822
Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.
Loss of PBRM1 expression is associated with renal cell carcinoma progression.
Int. J. Cancer 132:E11-E17(2013)
PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342; PMCID=PMC4893961
Abaan O.D., Polley E.C., Davis S.R., Zhu Y.-L.J., Bilke S., Walker R.L., Pineda M.A., Gindin Y., Jiang Y., Reinhold W.C., Holbeck S.L., Simon R.M., Doroshow J.H., Pommier Y., Meltzer P.S.
The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.
Cancer Res. 73:4372-4382(2013)
PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018
Moghaddas Gholami A., Hahne H., Wu Z.-X., Auer F.J., Meng C., Wilhelm M., Kuster B.
Global proteome analysis of the NCI-60 cell line panel.
Cell Rep. 4:609-620(2013)
PubMed=24279929; DOI=10.1186/2049-3002-1-20; PMCID=PMC4178206
Dolfi S.C., Chan L.L.-Y., Qiu J., Tedeschi P.M., Bertino J.R., Hirshfield K.M., Oltvai Z.N., Vazquez A.
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates.
Cancer Metab. 1:20.1-20.13(2013)
PubMed=24670534; DOI=10.1371/journal.pone.0092047; PMCID=PMC3966786
Varma S., Pommier Y., Sunshine M., Weinstein J.N., Reinhold W.C.
High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner.
PLoS ONE 9:E92047-E92047(2014)
PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)
PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)
PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)
PubMed=25894527; DOI=10.1371/journal.pone.0121314; PMCID=PMC4404347
Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A.S., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:E0121314-E0121314(2015)
PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)
PubMed=26972028; DOI=10.1016/j.jprot.2016.03.008
Masuishi Y., Kimura Y., Arakawa N., Hirano H.
Identification of glycosylphosphatidylinositol-anchored proteins and omega-sites using TiO2-based affinity purification followed by hydrogen fluoride treatment.
J. Proteomics 139:77-83(2016)
PubMed=27141528; DOI=10.1016/j.dib.2016.04.001; PMCID=PMC4838930
Masuishi Y., Kimura Y., Arakawa N., Hirano H.
Data for identification of GPI-anchored peptides and omega-sites in cancer cell lines.
Data Brief 7:1302-1305(2016)
PubMed=27377824; DOI=10.1038/sdata.2016.52; PMCID=PMC4932877
Mestdagh P., Lefever S., Volders P.-J., Derveaux S., Hellemans J., Vandesompele J.
Long non-coding RNA expression profiling in the NCI60 cancer cell line panel using high-throughput RT-qPCR.
Sci. Data 3:160052-160052(2016)
PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Miroo T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)
PubMed=27807467; DOI=10.1186/s13100-016-0078-4; PMCID=PMC5087121
Zampella J.G., Rodic N., Yang W.R., Huang C.R.L., Welch J., Gnanakkan V.P., Cornish T.C., Boeke J.D., Burns K.H.
A map of mobile DNA insertions in the NCI-60 human cancer cell panel.
Mob. DNA 7:20.1-20.11(2016)
PubMed=27993170; DOI=10.1186/s12943-016-0565-8; PMCID=PMC5168717
Brodaczewska K.K., Szczylik C., Fiedorowicz M., Porta C., Czarnecka A.M.
Choosing the right cell line for renal cell cancer research.
Mol. Cancer 15:83.1-83.15(2016)
PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)
PubMed=28489074; DOI=10.1038/ncomms15165; PMCID=PMC5436135
Sinha R., Winer A.G., Chevinsky M.S., Jakubowski C., Chen Y.-B., Dong Y.-Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J.-D., Hakimi A.A.
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165.1-15165.10(2017)
PubMed=30260228; DOI=10.1021/acs.jproteome.8b00538
Knott M.E., Manzi M., Zabalegui N., Salazar M.O., Puricelli L.I., Monge M.E.
Metabolic footprinting of a clear cell renal cell carcinoma in vitro model for human kidney cancer detection.
J. Proteome Res. 17:3877-3888(2018)
PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)
PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)"
传代方法：1:2-1:4(首次传代建议1:2)
生长特性：贴壁生长
换液频率：每周2-3次
背景资料：该细胞源自一位原发性肾透明细胞癌患者。该细胞有微绒毛和桥粒，能在软琼脂上生长。此细胞生成一种PTH（甲状旁腺素）样的多肽，与乳癌和肺癌中生成的肽相似，其N端序列与PTH相似，具有PTH样活性，分子量为６０００D。
活细胞：通常具有透亮的外观、完整的细胞膜，以及清晰可见的细胞核和细胞质内的细胞器。对于贴壁细胞，活细胞能够牢固地贴附在培养皿或培养瓶上。死细胞：则呈现暗淡无光、细胞膜可能碎裂的状态，且无法有效贴壁(对于贴壁细胞而言)。悬浮细胞死细胞则可能表现出膜碎裂、内容物外泄等现象。不同类型的细胞具有特定的生长形态，如成纤维型细胞呈细长形状并附着在基质上生长，上皮型细胞呈多边形等。观察细胞是否保持其特有的生长形态也是判断细胞状态的重要依据。细胞培养员应及时记录细胞培养过程中的关键数据，包括细胞形态、染色结果、生长速度等。建立完善的数据记录系统，有助于追踪细胞状态的变化，并为后续分析提供依据。
┈订┈购┈热┈线：1┈5┈8┈0┈0┈5┈7┈6┈8┈6┈7【微信同号】┈Q┈Q：3┈3┈0┈7┈2┈0┈4┈2┈7┈1；
GM01766 Cells(拥有STR基因鉴定图谱)
COLO 699 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：TE671/RD Cells、UCD-MLA-144 Cells、ZR-75-30 Cells
HT-115 Cells;背景说明：结肠癌;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：32D.3 Cells、HSMC Cells、A-172 MG Cells
786-O[786-0]人肾透明细胞腺癌传代细胞长期复苏|送STR图谱
产品包装形式：复苏细胞：T25培养瓶(一瓶)或冻存细胞：1ml冻存管(两支)
来源说明：细胞主要来源ATCC、DSMZ等细胞库
传代的操作步骤注意事项：1)操作前要洗手，进入超净台后手要用75%酒精或0.2%擦试。试剂等瓶口也要擦试。2)点燃酒精灯，操作在火焰附近进行，耐热物品要经常在火焰上烧灼，金属器械烧灼时间不能太长，以免退火，并冷却后才能夹取组织，吸取过营养的用具不能再烧灼，以免烧焦形成碳膜。3)操作动作要准确敏捷，但又不能太快，以防空气流动，增加污染机会。4)不能用手触已消毒器皿的工作部分，工作台面上用品要布局合理。5)瓶子开口后要尽量保持45℃斜位。6)吸溶的吸管等不能混用。贴壁细胞传代的操作步骤：1)吸除培养瓶内旧培养。2)向瓶内加入胰蛋白酶和EDA混合少许，以能覆满瓶底为限。3)置温箱中2-5分钟，当发现细胞质回缩，细胞间隙增大后，立即终止消化。4)吸除消化，向瓶内注入Hanks数毫升，轻轻转动培养瓶，把残余消化冲掉。注意加Hanks冲洗细胞时，动作要轻，以免把已松动的细胞冲掉流失，如用胰蛋白酶单独消化，吸除胰蛋白酶后，可不用Hanks冲洗，直接加入培养。5)用吸管吸取营养轻轻反复吹打瓶壁细胞，使之从瓶壁脱离形成细胞悬。6)计数板计数后，把细胞悬分成等份分装入数个培养瓶中，置温箱中培养。悬浮细胞传代的操作步骤：1)吸出细胞培养，放入离心管中，离心1000rpm5分钟。2)吸掉上清，加入适量之新鲜培养基，混和均匀后，依稀释比例转移至新的培养瓶中，以正常培养条件培养。
物种来源：Human\Mouse\Rat\Others
TE13 Cells;背景说明：食管鳞癌；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：H1944 Cells、GM05372 Cells、CT26.CL25 Cells
KM933 Cells;背景说明：B淋巴；EBV转化;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：悬浮;形态特性：详见产品说明;相关产品有：Psi-2 DAP Cells、SK-Mel1 Cells、BT549 Cells
ES-2 Cells;背景说明：ES-２细胞系源于一位４７岁黑人女性的临床卵巢透明细胞癌手术标本。该细胞对中低剂量的阿霉素，顺铂，双乙基亚硝脲，表鬼臼毒素吡喃葡糖苷等化疗药物有一定耐药性。该细胞少量表达糖蛋白P。;传代方法：１：３传代，２-３天传一次;生长特性：贴壁生长;形态特性：上皮样;相关产品有：OCI/AML-2 Cells、GMK,BSC-1 Cells、TOV-112 Cells
786-O[786-0]人肾透明细胞腺癌传代细胞长期复苏|送STR图谱
形态特性：上皮细胞样
┈订┈购┈热┈线：1┈5┈8┈0┈0┈5┈7┈6┈8┈6┈7【微信同号】┈Q┈Q：3┈3┈0┈7┈2┈0┈4┈2┈7┈1；
ATCC细胞库(American Type Culture Colection)，该中心一直致力于细胞分类、鉴定和保藏工作。ATCC是全球最大的生物资源保藏中心，ATCC通过行业标准产品、服务和创新解决方案支持全球学术、政府、生物技术、制药、食品、农业和工业领域的科学进步。ATCC提供的服务和定制解决方案包括细胞和微生物培养、鉴定、生物衍生物的开发和生产、性能测试和生物资源保藏服务。美国国家标准协会(ANSI)认可了ATCC标准开发组织，并制定了标准协议，以确保生物材料的可靠性和可重复性。ATCC的使命是为了获取、鉴定、保存、开发、标准化和分发生物资源和生物信息，以提高和应用生物科学知识。
HCC366 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：L-363 Cells、KYSE70 Cells、GM00637H Cells
A549 ATCC Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：ECC1 Cells、NCI-H2023 Cells、NCIH2122 Cells
MDA231-LM2 Cells;背景说明：乳腺癌;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：NCI H716 Cells、MA-782 Cells、Reuber H-35 Cells
HCCLM6 Cells;背景说明：肝癌;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：LM3 Cells、639 V Cells、Capan 2 Cells
H-146 Cells;背景说明：详见相关文献介绍;传代方法：１：２—１：６传代，每周换液２-３次;生长特性：悬浮生长;形态特性：上皮细胞;相关产品有：HCC-1359 Cells、H64 Cells、KALS1 Cells
SNUC1 Cells;背景说明：详见相关文献介绍;传代方法：每３-５天换液。;生长特性：悬浮生长;形态特性：上皮细胞;相关产品有：HSC3 Cells、PY8119 Cells、AML-EOL-1 Cells
PG13 Cells;背景说明：胚胎；成纤维 Cells;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：MNNG-HOS Cells、MDST8 Cells、FRTL-5 Cells
KYSE 520 Cells;背景说明：食管鳞癌；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：H2122 Cells、RC-4B/C Cells、NCIH889 Cells
LAPC4 Cells;背景说明：前列腺癌；淋巴结转移；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：EVSAT Cells、SNU886 Cells、Bovine ENDometrial cells Cells
HS688AT Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代;生长特性：贴壁生长;形态特性：成纤维细胞;相关产品有：OPM2 Cells、COV 504 Cells、Adeno 293 Cells
Centre Antoine Lacassagne-12T Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：MDA MB 134VI Cells、HOS Cells、Bronchial Epithelium transformed with Ad12-SV40 2B Cells
HeLa229 Cells;背景说明：宫颈癌；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：RT-BM-1 Cells、CA-46 Cells、OCI-Ly 7 Cells
Neuro 2a Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：４传代；２-３天换液１次;生长特性：贴壁生长;形态特性：详见产品说明;相关产品有：A10 Cells、HCC-95 Cells、OLN 93 Cells
MCA-205 Cells;背景说明：纤维肉瘤;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：HEK-293 c18 Cells、NCI-SNU-1040 Cells、Nb2a Cells
Murine Long bone Osteocyte-Y4 Cells;背景说明：骨；SV４０转化;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：SCC VII Cells、OCI/AML5 Cells、MONO-MAC 6 Cells
Y79 Cells;背景说明：１９７１年１月，该细胞由ReidTW及其同事从病人右眼切除的肿瘤进行原代培养建立而成，此病人有很强的视网膜母细胞瘤的母系家族遗传性。该细胞的超微结构，如核膜内折、三层膜结构、大的被膜小泡、环孔板、微管、中心粒、基粒等都与原始肿瘤相似。;传代方法：１：２传代;生长特性：悬浮生长;形态特性：圆形，成簇生长;相关产品有：CHL-1 Cells、MAVER Cells、NCI-H211 Cells
Calu6 Cells;背景说明：详见相关文献介绍;传代方法：消化２０分钟。１：２。５-６天长满。;生长特性：贴壁生长;形态特性：上皮细胞;相关产品有：Ra #1 Cells、RPMI8402 Cells、HEK-A Cells
Abcam HEK293T SDHD KO Cells(拥有STR基因鉴定图谱)
AG12657 Cells(拥有STR基因鉴定图谱)
BayGenomics ES cell line RRC013 Cells(拥有STR基因鉴定图谱)
BayGenomics ES cell line XE422 Cells(拥有STR基因鉴定图谱)
BY00348 Cells(拥有STR基因鉴定图谱)
CSCR19i-indCFANCA Cells(拥有STR基因鉴定图谱)
DA04470 Cells(拥有STR基因鉴定图谱)
DD0698 Cells(拥有STR基因鉴定图谱)
MESSA Dx5 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：８传代；每周２-３次。;生长特性：贴壁生长;形态特性：成纤维细胞样 ;相关产品有：PASMCS Cells、CCD19-Lu Cells、U251 Cells
NCI-H522 Cells;背景说明：详见相关文献介绍;传代方法：１：３-１：６传代；每周换液２-３次。;生长特性：贴壁生长;形态特性：上皮样;相关产品有：SJCRH30 Cells、RIN-m 14B Cells、H2170 Cells
786-O[786-0]人肾透明细胞腺癌传代细胞长期复苏|送STR图谱
CEMx721.174.T2 Cells;背景说明：详见相关文献介绍;传代方法：１：３—１：６传代，每周换液２—３次;生长特性：悬浮生长;形态特性：淋巴母细胞样;相关产品有：Tn5B1-4 Cells、TE-13 Cells、2BS Cells
L-cell Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：MC116 Cells、TW-039 Cells、NCI-H1755 Cells
CF PAC-1 Cells;背景说明：详见相关文献介绍;传代方法：１：３-１０传代；２-３天换液１次。;生长特性：贴壁生长;形态特性：上皮细胞;相关产品有：WSU-DLCL(2) Cells、NCI-H841 Cells、TE12 Cells
A-375.S2 Cells;背景说明：详见相关文献介绍;传代方法：１：２传代;生长特性：贴壁生长;形态特性：上皮样;相关产品有：LN-229 Cells、H35 Cells、HCT 15 Cells
ND7/23 Cells;背景说明：神经母细胞瘤;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：BA/F3 Cells、LN229 Cells、P3X63 Ag8 Cells
D-341Med Cells;背景说明：详见相关文献介绍;传代方法：每周换液２-３次。;生长特性：悬浮生长;形态特性：髓母细胞样;相关产品有：MT2 Cells、hTERT-HPNE Cells、RPMI #8226 Cells
3E9 [Mouse hybridoma against DHAV VP3] Cells(拥有STR基因鉴定图谱)
SUP-M2 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：SW1271 Cells、D283MED Cells、Baby Hamster Kidney-21 Cells
GI-1 Cells;背景说明：详见相关文献介绍;传代方法：１：２传代;生长特性：贴壁生长;形态特性：上皮样;相关产品有：SUDHL-10 Cells、SW-1088 Cells、National Medical Center-Glioma 1 Cells
┈订┈购┈热┈线：1┈5┈8┈0┈0┈5┈7┈6┈8┈6┈7【微信同号】┈Q┈Q：3┈3┈0┈7┈2┈0┈4┈2┈7┈1；
OVCA 433 Cells;背景说明：卵巢癌；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：Japanese Tissue Culture-28 Cells、HPAF-II Cells、H-1944 Cells
LNCaP-C4-2 Cells;背景说明：前列腺癌；左锁骨上淋巴结转移；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：C6 Cells、QGY Cells、HT29 Cells
hTERT-RPE Cells;背景说明：视网膜色素上皮；hTERT永生；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：NPA'87 Cells、MEG-01 Cells、Adeno-293 Cells
NHA Cells;背景说明：星形胶质 Cells;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：MPP-89 Cells、CNE Cells、NIE 115 Cells
NB9 Cells;背景说明：详见相关文献介绍;传代方法：１：１０ １：５０每２ - ３周；每周换液２-３次。;生长特性：贴壁生长;形态特性：成神经细胞;相关产品有：WM451 Cells、A-9 Cells、MPC11 Cells
HOS(TE85) Cells;背景说明：骨肉瘤；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：HAVSMC Cells、NCI-841 Cells、NCIH2347 Cells
GM10071 Cells(拥有STR基因鉴定图谱)
HAP1 C10orf32 (-) 2 Cells(拥有STR基因鉴定图谱)
HO1-N1 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁生长;形态特性：上皮样;相关产品有：SU-DHL-8 Cells、Dakiki Cells、YH-13 Cells
T-ALL1 Cells;背景说明：该细胞源于一名复发T-ALL（急性T淋巴细胞性白血病）的儿童的外周血；具有很强的细胞毒性，体内体外实验中都能破坏肿瘤细胞；IL-２可使细胞更好地生长；α/β TCR阳性，γ/δ TCR阴性；可产生IFNγ、TNF-α和GM-CSF。;传代方法：维持细胞密度在４×１０５-１×１０６ cells/ml之间，２-３天换液１次 ;生长特性：悬浮生长;形态特性：淋巴母细胞;相关产品有：RS(4;11) Cells、HFE-145 Cells、SKMel-5 Cells
PL12 Cells;背景说明：详见相关文献介绍;传代方法：１：２传代;生长特性：贴壁生长;形态特性：上皮样;相关产品有：16HBE140 Cells、PA-TU-8988S Cells、HIBEpiC Cells
MDAPCa-2b Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：４传代，２-３天换液１次。;生长特性：贴壁生长;形态特性：上皮细胞;相关产品有：TOV-112D Cells、U-373MG Cells、HS-683 Cells
EHEB Cells;背景说明：B细胞白血病；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：悬浮;形态特性：详见产品说明;相关产品有：KYSE-270 Cells、SK-N-DZ Cells、Rh30 Cells
KS-1 [Human glioblastoma] Cells;背景说明：详见相关文献介绍;传代方法：１：２传代;生长特性：贴壁生长;形态特性：成纤维细胞;相关产品有：BEL 7405 Cells、BC-021 Cells、TE-7 Cells
CHO Lec1 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：Caco-2/BBe Cells、Adult Retinal Pigment Epithelial cell line-19 Cells、A375S2 Cells
RCC10 RGB Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：HCC1187 Cells、HEC-1B Cells、Rat Skin 1 Cells
HG03493 Cells(拥有STR基因鉴定图谱)
IDG-HEK293T-CALHM4-V5-OE Cells(拥有STR基因鉴定图谱)
LP-2 Cells(拥有STR基因鉴定图谱)
NCI-H838 KRAS (G12V/+9n) Cells(拥有STR基因鉴定图谱)
PathHunter U2OS MCHR2 beta-arrestin Cells(拥有STR基因鉴定图谱)
TS/A-pc Cells(拥有STR基因鉴定图谱)
UKWi001-A Cells(拥有STR基因鉴定图谱)
HEV0041 Cells(拥有STR基因鉴定图谱)
H87 Cells;背景说明：NCI-N８７细胞表达表面糖蛋白癌胚抗原(CEA)和TAG７２,并且没有左旋多巴胺脱羧酶(DDC)活性。它们的血管活性的肠肽(VIP)受体活性极低并缺乏胃泌激素受体。它们表达蕈毒碱胆碱受体。没有证据表明存在N-myc,L-myc,myb和EGF受体基因的重组。这个细胞株表达的c-myc和c-erb-B２RNA水平与其它细胞株相当。以下基因不表达:N-myc,L-myc,c-cis,IGF-２,或胃泌激素释放肽。报道NCI-N８７细胞的植板率为４.３%。;传代方法：消化１５-２０分钟。１：２。４-５天长满。;生长特性：贴壁生长;形态特性：上皮细胞样;相关产品有：LNCaP-ATCC Cells、HEK293F Cells、RC-2 Cells
SW 780 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：Hs-695-T Cells、H82sclc Cells、H-1734 Cells
HANK Cells;背景说明：NK/T细胞淋巴瘤；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：悬浮;形态特性：详见产品说明;相关产品有：BJAB-1 Cells、HCT/FU Cells、SUP-B1 Cells
Sun Yat-sen university Ophtalmic center-Retinoblastoma 50 Cells;背景说明：视网膜母细胞瘤；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：悬浮;形态特性：详见产品说明;相关产品有：Hs822T Cells、SNU-449 Cells、U266 B1 Cells
HCT.116 Cells;背景说明：结肠腺癌；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：SO-Rb 50 Cells、P3-X63-Ag8-653 Cells、SHSY-5Y Cells
HCT.116 Cells;背景说明：结肠腺癌；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：SO-Rb 50 Cells、P3-X63-Ag8-653 Cells、SHSY-5Y Cells
HS-766-T Cells;背景说明：详见相关文献介绍;传代方法：１：２—１：８传代，每周换液２—３次;生长特性：贴壁生长;形态特性：上皮细胞;相关产品有：HuCCT-1 Cells、COLO 394 Cells、ONS-76 Cells
HBE Cells;背景说明：详见相关文献介绍;传代方法：１：２传代;生长特性：贴壁生长 ;形态特性：详见产品说明;相关产品有：NCI-446 Cells、RL Cells、mIMCD3 Cells
HEC-1-B Cells;背景说明：该细胞是H.Kuramoto１９６８年分离的HEC-１-A细胞亚株。不同於HEC-A-１的是：该亚株在培养第１３５天到１９０天之间表现出稳定的生长周期，且重现扁平，与亲本细胞系相比更具铺路石式样。此外主要染色体组是亲本细胞的两倍。;传代方法：１：３传代，２-３天换液一次;生长特性：贴壁生长;形态特性：上皮样;相关产品有：QBC939 Cells、BrCL15 Cells、KP-4 Cells
526 Cells;背景说明：黑色素瘤;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：SK-RC-52 Cells、LUDLU-1 Cells、H548 Cells
HCET Cells;背景说明：角膜上皮细胞；Ad-SV４０转化；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：NCI H295R Cells、FM88 Cells、EA.hy 926 Cells
HCT116 Cells;背景说明：结肠腺癌；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：Rat podocyte Cells、MKN 45 Cells、SK-N-BE(2)C Cells
SW-948 Cells;背景说明：详见相关文献介绍;传代方法：１：２—１：５传代，每周换液１-２次;生长特性：贴壁生长;形态特性：上皮细胞样;相关产品有：SW 1573 Cells、CL-34 Cells、SKG-3a Cells
786-O[786-0]人肾透明细胞腺癌传代细胞长期复苏|送STR图谱
H2081 Cells;背景说明：详见相关文献介绍;传代方法：随细胞的密度而增加;生长特性：悬浮生长;形态特性：聚团悬浮;相关产品有：hFOB Cells、NCI-H2171 Cells、CP70 Cells
Hs 888Lu Cells;背景说明：详见相关文献介绍;传代方法：１：２传代;生长特性：贴壁生长 ;形态特性：详见产品说明;相关产品有：Ramos 2G6 4C10 Cells、KP2 Cells、KYSE70 Cells
SBDS-iPS1 Cells(拥有STR基因鉴定图谱)
GM17346 Cells;背景说明：１９６７年，该细胞系KleinE和KleinG建系，源于一名１６岁患有Burkitt＇s淋巴瘤的黑人男性，beta-２-微球蛋白阴性，表达EBNA,VCA，sIg。该细胞携带EB病毒，是一个典型的B淋巴母细胞系，可用于白血病发病机制的研究。;传代方法：１：２传代;生长特性：悬浮生长;形态特性：淋巴母细胞样;相关产品有：A-375.S2 Cells、Line 697 Cells、NCIH2342 Cells
Tj-905 Cells;背景说明：胶质瘤;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：GH 3 Cells、COLO678 Cells、mousepodocyte Cells
SF539 Cells;背景说明：胶质瘤；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：K562 Cells、SJ-Rh 30 Cells、3T3NIH Cells
WM-266-mel Cells;背景说明：详见相关文献介绍;传代方法：１：２传代;生长特性：贴壁生长;形态特性：详见产品说明;相关产品有：H2066 Cells、SK-RC-39 Cells、SPC-A1 Cells
┈订┈购┈热┈线：1┈5┈8┈0┈0┈5┈7┈6┈8┈6┈7【微信同号】┈Q┈Q：3┈3┈0┈7┈2┈0┈4┈2┈7┈1；
MOLM-13 Cells;背景说明：急性髓系白血病；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：悬浮;形态特性：详见产品说明;相关产品有：NCI N87 Cells、Sol8 Cells、WEHI3B Cells
KASUMI1 Cells;背景说明：详见相关文献介绍;传代方法：１：２传代。３天内可长满。;生长特性：悬浮生长;形态特性：原粒细胞;相关产品有：9L Cells、Tca-8113 Cells、NCI-H295R Cells
Ramos-RA1 Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：H-740 Cells、H2052_MM Cells、870 Cells
H-2141 Cells;背景说明：详见相关文献介绍;传代方法：３-４天换液１次。;生长特性：悬浮生长;形态特性：聚团悬浮;相关产品有：67NR Cells、TK10 Cells、bEND.3 Cells
EFM-19 Cells;背景说明：乳腺管癌；胸腔积液转移；女性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁;形态特性：详见产品说明;相关产品有：SKMES Cells、RD-ES Cells、HT-115 Cells
RS411 Cells;背景说明：详见相关文献介绍;传代方法：每周２-３次;生长特性：悬浮生长;形态特性：成淋巴细胞;相关产品有：NT2-D1 Cells、SF-539 Cells、HCC2185 Cells
NALM 6 Cells;背景说明：急性B淋巴细胞白血病；男性;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：悬浮;形态特性：详见产品说明;相关产品有：MDA-1386 Cells、OVCA 420 Cells、HUT-125 Cells
CCD-1112sk Cells;背景说明：详见相关文献介绍;传代方法：１：２-１：３传代；每周换液２-３次。;生长特性：贴壁或悬浮，详见产品说明部分;形态特性：详见产品说明;相关产品有：Renal Carcinoma Cells、NCI-H102 Cells、SW954 Cells
Calu-6 Cells;背景说明：详见相关文献介绍;传代方法：消化２０分钟。１：２。５-６天长满。;生长特性：贴壁生长;形态特性：上皮细胞;相关产品有：RCK8 Cells、373MG Cells、MMAc-SF Cells
OVCAR-3 Cells;背景说明：该细胞１９８２年由T.C. Hamilton等建系，源自一位６０卵巢腺癌的腹水，是卵巢癌抗药性研究的模型。;传代方法：１：２—１：４传代，每周换液２—３次;生长特性：贴壁生长;形态特性：上皮细胞样;相关产品有：AN3-CA Cells、L-Wnt-3A Cells、KNS42 Cells
BayGenomics ES cell line CSJ039 Cells(拥有STR基因鉴定图谱)
BayGenomics ES cell line SYA283 Cells(拥有STR基因鉴定图谱)
CC 92 Cells(拥有STR基因鉴定图谱)
M-1 [Mouse kidney] Cells(拥有STR基因鉴定图谱)
RAW264.7 clone C5 Cells(拥有STR基因鉴定图谱)
RSC96 L-periaxin KO Cells(拥有STR基因鉴定图谱)
" "PubMed=2041050; DOI=10.1093/jnci/83.11.757
Monks A., Scudiero D.A., Skehan P., Shoemaker R.H., Paull K.D., Vistica D.T., Hose C.D., Langley J., Cronise P., Vaigro-Wolff A., Gray-Goodrich M., Campbell H., Mayo J.G., Boyd M.R.
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
J. Natl. Cancer Inst. 83:757-766(1991)
PubMed=7915601; DOI=10.1038/ng0594-85
Gnarra J.R., Tory K., Weng Y.-K., Schmidt L.S., Wei M.H., Li H., Latif F., Liu S., Chen F., Duh F.-M., Lubensky I.A., Duan D.-S.R., Florence C., Pozzatti R., Walther M.M., Bander N.H., Grossman H.B., Brauch H., Pomer S., Brooks J.D., Isaacs W.B., Lerman M.I., Zbar B., Linehan W.M.
Mutations of the VHL tumour suppressor gene in renal carcinoma.
Nat. Genet. 7:85-90(1994)
PubMed=10700174; DOI=10.1038/73432
Ross D.T., Scherf U., Eisen M.B., Perou C.M., Rees C., Spellman P.T., Iyer V.R., Jeffrey S.S., van de Rijn M., Waltham M.C., Pergamenschikov A., Lee J.C.F., Lashkari D., Shalon D., Myers T.G., Weinstein J.N., Botstein D., Brown P.O.
Systematic variation in gene expression patterns in human cancer cell lines.
Nat. Genet. 24:227-235(2000)
PubMed=15585611; DOI=10.1158/1078-0432.CCR-04-0072
Tykodi S.S., Warren E.H., Thompson J.A., Riddell S.R., Childs R.W., Otterud B.E., Leppert M.F., Storb R., Sandmaier B.M.
Allogeneic hematopoietic cell transplantation for metastatic renal cell carcinoma after nonmyeloablative conditioning: toxicity, clinical response, and immunological response to minor histocompatibility antigens.
Clin. Cancer Res. 10:7799-7811(2004)
PubMed=15748285; DOI=10.1186/1479-5876-3-11; PMCID=PMC555742
Adams S., Robbins F.-M., Chen D., Wagage D., Holbeck S.L., Morse H.C. 3rd, Stroncek D., Marincola F.M.
HLA class I and II genotype of the NCI-60 cell lines.
J. Transl. Med. 3:11.1-11.8(2005)
PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433; PMCID=PMC2705832
Ikediobi O.N., Davies H.R., Bignell G.R., Edkins S., Stevens C., O'Meara S., Santarius T., Avis T., Barthorpe S., Brackenbury L., Buck G., Butler A.P., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Hunter C., Jenkinson A., Jones D., Kosmidou V., Lugg R., Menzies A., Miroo T., Parker A., Perry J., Raine K.M., Richardson D., Shepherd R., Small A., Smith R., Solomon H., Stephens P.J., Teague J.W., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Reinhold W.C., Weinstein J.N., Stratton M.R., Futreal P.A., Wooster R.
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.
Mol. Cancer Ther. 5:2606-2612(2006)
PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921; PMCID=PMC4020356
Lorenzi P.L., Reinhold W.C., Varma S., Hutchinson A.A., Pommier Y., Chanock S.J., Weinstein J.N.
DNA fingerprinting of the NCI-60 cell line panel.
Mol. Cancer Ther. 8:713-724(2009)
PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)
PubMed=22068913; DOI=10.1073/pnas.1111840108; PMCID=PMC3219108
Gillet J.-P., Calcagno A.M., Varma S., Marino M., Green L.J., Vora M.I., Patel C., Orina J.N., Eliseeva T.A., Singal V., Padmanabhan R., Davidson B., Ganapathi R., Sood A.K., Rueda B.R., Ambudkar S.V., Gottesman M.M.
Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance.
Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011)
PubMed=22185343; DOI=10.1186/1471-2407-11-523; PMCID=PMC3292516
Matsuura K., Nakada C., Mashio M., Narimatsu T., Yoshimoto T., Tanigawa M., Tsukamoto Y., Hijiya N., Takeuchi I., Nomura T., Sato F., Mimata H., Seto M., Moriyama M.
Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma.
BMC Cancer 11:523.1-523.10(2011)
PubMed=22347499; DOI=10.1371/journal.pone.0031628; PMCID=PMC3276511
Ruan X.-Y., Kocher J.-P.A., Pommier Y., Liu H.-F., Reinhold W.C.
Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap trios, and relation to fragile site location.
PLoS ONE 7:E31628-E31628(2012)
PubMed=22384151; DOI=10.1371/journal.pone.0032096; PMCID=PMC3285665
Lee J.-S., Kim Y.K., Kim H.J., Hajar S., Tan Y.L., Kang N.-Y., Ng S.H., Yoon C.N., Chang Y.-T.
Identification of cancer cell-line origins using fluorescence image-based phenomic screening.
PLoS ONE 7:E32096-E32096(2012)
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Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)
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Jain M., Nilsson R., Sharma S., Madhusudhan N., Kitami T., Souza A.L., Kafri R., Kirschner M.W., Clish C.B., Mootha V.K.
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.
Science 336:1040-1044(2012)
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Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.
Loss of PBRM1 expression is associated with renal cell carcinoma progression.
Int. J. Cancer 132:E11-E17(2013)
PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342; PMCID=PMC4893961
Abaan O.D., Polley E.C., Davis S.R., Zhu Y.-L.J., Bilke S., Walker R.L., Pineda M.A., Gindin Y., Jiang Y., Reinhold W.C., Holbeck S.L., Simon R.M., Doroshow J.H., Pommier Y., Meltzer P.S.
The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.
Cancer Res. 73:4372-4382(2013)
PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018
Moghaddas Gholami A., Hahne H., Wu Z.-X., Auer F.J., Meng C., Wilhelm M., Kuster B.
Global proteome analysis of the NCI-60 cell line panel.
Cell Rep. 4:609-620(2013)
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Dolfi S.C., Chan L.L.-Y., Qiu J., Tedeschi P.M., Bertino J.R., Hirshfield K.M., Oltvai Z.N., Vazquez A.
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates.
Cancer Metab. 1:20.1-20.13(2013)
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Varma S., Pommier Y., Sunshine M., Weinstein J.N., Reinhold W.C.
High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner.
PLoS ONE 9:E92047-E92047(2014)
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Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)
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Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
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Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A.S., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.
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Masuishi Y., Kimura Y., Arakawa N., Hirano H.
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Mestdagh P., Lefever S., Volders P.-J., Derveaux S., Hellemans J., Vandesompele J.
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Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Miroo T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)
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Zampella J.G., Rodic N., Yang W.R., Huang C.R.L., Welch J., Gnanakkan V.P., Cornish T.C., Boeke J.D., Burns K.H.
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Brodaczewska K.K., Szczylik C., Fiedorowicz M., Porta C., Czarnecka A.M.
Choosing the right cell line for renal cell cancer research.
Mol. Cancer 15:83.1-83.15(2016)
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Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)
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Sinha R., Winer A.G., Chevinsky M.S., Jakubowski C., Chen Y.-B., Dong Y.-Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J.-D., Hakimi A.A.
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165.1-15165.10(2017)
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Knott M.E., Manzi M., Zabalegui N., Salazar M.O., Puricelli L.I., Monge M.E.
Metabolic footprinting of a clear cell renal cell carcinoma in vitro model for human kidney cancer detection.
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Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)
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Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)"
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文献和实验该产品被引用文献
"PubMed=2041050; DOI=10.1093/jnci/83.11.757
Monks A., Scudiero D.A., Skehan P., Shoemaker R.H., Paull K.D., Vistica D.T., Hose C.D., Langley J., Cronise P., Vaigro-Wolff A., Gray-Goodrich M., Campbell H., Mayo J.G., Boyd M.R.
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
J. Natl. Cancer Inst. 83:757-766(1991)
PubMed=7915601; DOI=10.1038/ng0594-85
Gnarra J.R., Tory K., Weng Y.-K., Schmidt L.S., Wei M.H., Li H., Latif F., Liu S., Chen F., Duh F.-M., Lubensky I.A., Duan D.-S.R., Florence C., Pozzatti R., Walther M.M., Bander N.H., Grossman H.B., Brauch H., Pomer S., Brooks J.D., Isaacs W.B., Lerman M.I., Zbar B., Linehan W.M.
Mutations of the VHL tumour suppressor gene in renal carcinoma.
Nat. Genet. 7:85-90(1994)
PubMed=10700174; DOI=10.1038/73432
Ross D.T., Scherf U., Eisen M.B., Perou C.M., Rees C., Spellman P.T., Iyer V.R., Jeffrey S.S., van de Rijn M., Waltham M.C., Pergamenschikov A., Lee J.C.F., Lashkari D., Shalon D., Myers T.G., Weinstein J.N., Botstein D., Brown P.O.
Systematic variation in gene expression patterns in human cancer cell lines.
Nat. Genet. 24:227-235(2000)
PubMed=15585611; DOI=10.1158/1078-0432.CCR-04-0072
Tykodi S.S., Warren E.H., Thompson J.A., Riddell S.R., Childs R.W., Otterud B.E., Leppert M.F., Storb R., Sandmaier B.M.
Allogeneic hematopoietic cell transplantation for metastatic renal cell carcinoma after nonmyeloablative conditioning: toxicity, clinical response, and immunological response to minor histocompatibility antigens.
Clin. Cancer Res. 10:7799-7811(2004)
PubMed=15748285; DOI=10.1186/1479-5876-3-11; PMCID=PMC555742
Adams S., Robbins F.-M., Chen D., Wagage D., Holbeck S.L., Morse H.C. 3rd, Stroncek D., Marincola F.M.
HLA class I and II genotype of the NCI-60 cell lines.
J. Transl. Med. 3:11.1-11.8(2005)
PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433; PMCID=PMC2705832
Ikediobi O.N., Davies H.R., Bignell G.R., Edkins S., Stevens C., O'Meara S., Santarius T., Avis T., Barthorpe S., Brackenbury L., Buck G., Butler A.P., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Hunter C., Jenkinson A., Jones D., Kosmidou V., Lugg R., Menzies A., Miroo T., Parker A., Perry J., Raine K.M., Richardson D., Shepherd R., Small A., Smith R., Solomon H., Stephens P.J., Teague J.W., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Reinhold W.C., Weinstein J.N., Stratton M.R., Futreal P.A., Wooster R.
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.
Mol. Cancer Ther. 5:2606-2612(2006)
PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921; PMCID=PMC4020356
Lorenzi P.L., Reinhold W.C., Varma S., Hutchinson A.A., Pommier Y., Chanock S.J., Weinstein J.N.
DNA fingerprinting of the NCI-60 cell line panel.
Mol. Cancer Ther. 8:713-724(2009)
PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)
PubMed=22068913; DOI=10.1073/pnas.1111840108; PMCID=PMC3219108
Gillet J.-P., Calcagno A.M., Varma S., Marino M., Green L.J., Vora M.I., Patel C., Orina J.N., Eliseeva T.A., Singal V., Padmanabhan R., Davidson B., Ganapathi R., Sood A.K., Rueda B.R., Ambudkar S.V., Gottesman M.M.
Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance.
Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011)
PubMed=22185343; DOI=10.1186/1471-2407-11-523; PMCID=PMC3292516
Matsuura K., Nakada C., Mashio M., Narimatsu T., Yoshimoto T., Tanigawa M., Tsukamoto Y., Hijiya N., Takeuchi I., Nomura T., Sato F., Mimata H., Seto M., Moriyama M.
Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma.
BMC Cancer 11:523.1-523.10(2011)
PubMed=22347499; DOI=10.1371/journal.pone.0031628; PMCID=PMC3276511
Ruan X.-Y., Kocher J.-P.A., Pommier Y., Liu H.-F., Reinhold W.C.
Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap trios, and relation to fragile site location.
PLoS ONE 7:E31628-E31628(2012)
PubMed=22384151; DOI=10.1371/journal.pone.0032096; PMCID=PMC3285665
Lee J.-S., Kim Y.K., Kim H.J., Hajar S., Tan Y.L., Kang N.-Y., Ng S.H., Yoon C.N., Chang Y.-T.
Identification of cancer cell-line origins using fluorescence image-based phenomic screening.
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Cell Rep. 4:609-620(2013)
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Nat. Biotechnol. 33:306-312(2015)
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Nature 520:307-311(2015)
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Genome Med. 7:118.1-118.7(2015)
PubMed=26972028; DOI=10.1016/j.jprot.2016.03.008
Masuishi Y., Kimura Y., Arakawa N., Hirano H.
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J. Proteomics 139:77-83(2016)
PubMed=27141528; DOI=10.1016/j.dib.2016.04.001; PMCID=PMC4838930
Masuishi Y., Kimura Y., Arakawa N., Hirano H.
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Data Brief 7:1302-1305(2016)
PubMed=27377824; DOI=10.1038/sdata.2016.52; PMCID=PMC4932877
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