Trp53 Rabbit Monoclonal Antibo

ProductName：Trp53 Rabbit Monoclonal Antibody [Clone ID: R01-2B9]
description：p53 Rabbit monoclonal Antibody
symbol：Tp53
synonyms：bbl; bfy; bhy; p44; p53; Tp53
locusid：22059
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：P02340
Applications：IF, IP, WB
CNdelivery：2周
RecommendDilution：WB: 1/1000
ICC/IF: 1/20
IP: 1/20
Reactivity：Mouse
Immunogen：Recombinant protein of mouse p53
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：transformation related protein 53
Background：Swiss-Prot Acc.P02340.Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression . Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis, but seems to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 44 kDa; Observed MW: 53 kDa