STAT3 Rabbit Monoclonal Antibo

ProductName：STAT3 Rabbit Monoclonal Antibody [Clone ID: R05-7B2]
description：Phospho-STAT3 (Ser727) Rabbit monoclonal Antibody
symbol：STAT3
synonyms：APRF; FLJ20882; HIES; MGC16063
locusid：6774
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：P40763
Applications：IF, WB
CNdelivery：2周
RecommendDilution：WB: 1/1000
ICC/IF: 1/20
Reactivity：Human, Rat
Immunogen：A synthetic phosphopeptide corresponding to residues surrounding Ser727 of human STAT3 (Phosphorylated)
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：signal transducer and activator of transcription 3
Background：Swiss-Prot Acc.P40763.Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation . May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion .
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 88 kDa; Observed MW: 88 kDa