STAT1 Rabbit Monoclonal Antibo

ProductName：STAT1 Rabbit Monoclonal Antibody [Clone ID: R07-7A3]
description：STAT1 Rabbit monoclonal Antibody
symbol：STAT1
synonyms：DKFZp686B04100; ISGF-3; OTTHUMP00000205845; STAT91
locusid：6772
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：P42224
Applications：IF, IP, WB
CNdelivery：2周
RecommendDilution：WB: 1/2000-1/10000
ICC/IF: 1/500-1/1000
IP: 1/20
Reactivity：Human
Immunogen：A synthetic peptide of human STAT1
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：signal transducer and activator of transcription 1
Background：Swiss-Prot Acc.P42224.Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 87 kDa; Observed MW: 87 kDa