POT1 Rabbit Monoclonal Antibod

ProductName：POT1 Rabbit Monoclonal Antibody [Clone ID: R06-9I1]
description：POT1 Rabbit monoclonal Antibody
symbol：POT1
synonyms：DKFZp586D211; hPot1; OTTHUMP00000211676
locusid：25913
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：Q9NUX5
Applications：WB
CNdelivery：2周
RecommendDilution：WB: 1/1000-1/5000
Reactivity：Human, Mouse, Rat
Immunogen：A synthetic peptide of human POT1
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：protection of telomeres 1
Background：Swiss-Prot Acc.Q9NUX5.Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 71 kDa; Observed MW: 71 kDa