Phospholipase A2 IIA (PLA2G2A)

ProductName：Phospholipase A2 IIA (PLA2G2A) Rabbit Monoclonal Antibody [Clone ID: R09-4F9]
description：Secretory Phospholipase A2 Rabbit monoclonal Antibody
symbol：PLA2G2A
synonyms：MOM1; NPS-PLA2; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; RASF-A; sPLA2
locusid：5320
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：P14555
Applications：WB
CNdelivery：2周
RecommendDilution：WB: 1/1000
Reactivity：Human, Mouse, Rat
Immunogen：A synthetic peptide of human Secretory phospholipase A2
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：phospholipase A2 group IIA
Background：Swiss-Prot Acc.P14555.Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536).
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 16 kDa; Observed MW: 16 kDa