MRE11 Rabbit Monoclonal Antibo

ProductName：MRE11 Rabbit Monoclonal Antibody [Clone ID: R03-6H9]
description：Mre11 Rabbit monoclonal Antibody
symbol：MRE11
synonyms：ATLD; HNGS1; MRE11; MRE11B
locusid：4361
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：P49959
Applications：IHC, WB
CNdelivery：2周
RecommendDilution：WB: 1/1000
IHC: 1/200
Reactivity：Human, Mouse, Rat
Immunogen：Recombinant protein of human Mre11
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：MRE11 homolog A, double strand break repair nuclease
Background：Swiss-Prot Acc.P49959.Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 81 kDa; Observed MW: 81 kDa