MAP2K1 Rabbit Monoclonal Antib

ProductName：MAP2K1 Rabbit Monoclonal Antibody [Clone ID: R07-1I6]
description：Phospho-MEK1 (Ser298) Rabbit monoclonal Antibody
symbol：MAP2K1
synonyms：null
locusid：56045605
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：Q02750
Applications：IF, WB
CNdelivery：2周
RecommendDilution：WB: 1/1000
ICC/IF: 1/50
Reactivity：Human, Mouse, Rat
Immunogen：A synthetic phosphopeptide corresponding to residues surrounding Ser298 of human MEK1 (Phosphorylated)
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：null
Background：Swiss-Prot Acc.Q02750.Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 43 kDa; Observed MW: 43 kDa