LAMP2 Rabbit Monoclonal Antibo

ProductName：LAMP2 Rabbit Monoclonal Antibody [Clone ID: R03-2J8]
description：LAMP2A Rabbit monoclonal Antibody
symbol：LAMP2
synonyms：CD107b; LAMP-2; LAMPB; LGP110
locusid：3920
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：P13473
Applications：IHC, IP, WB
CNdelivery：2周
RecommendDilution：WB: 1/1000
IHC: 1/20-1/1000
IP: 1/20
Reactivity：Human, Mouse
Immunogen：A synthetic peptide of human LAMP2A
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：lysosomal associated membrane protein 2
Background：Swiss-Prot Acc.P13473.Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation . Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 45 kDa; Observed MW: 110 kDa