ILF3 Rabbit Monoclonal Antibod

ProductName：ILF3 Rabbit Monoclonal Antibody [Clone ID: R04-9E8]
description：ILF3 Rabbit monoclonal Antibody
symbol：ILF3
synonyms：CBTF; DRBF; DRBP76; MMP4; MPHOSPH4; MPP4; NF-AT-90; NF90; NF110; NFAR; NFAR-1; NFAR2; TCP80; TCP110
locusid：3609
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：Q12906
Applications：IF, IHC, IP, WB
CNdelivery：2周
RecommendDilution：WB: 1/1000-1/5000
IHC: 1/50-1/200
ICC/IF: 1/20-1/50
IP: 1/20
Reactivity：Human, Mouse
Immunogen：A synthetic peptide of human ILF3
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：interleukin enhancer binding factor 3
Background：Swiss-Prot Acc.Q12906.RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 95 kDa; Observed MW: 95 kDa