Rb2 p130 (RBL2) Rabbit Monoclo

ProductName：Rb2 p130 (RBL2) Rabbit Monoclonal Antibody [Clone ID: R02-5D6]
description：Phospho-Rb2 p130 (Ser952) Rabbit monoclonal Antibody
symbol：RBL2
synonyms：FLJ26459; p130; PRB2; Rb2; RBR-2
locusid：5934
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：Q08999
Applications：IF, IHC, WB
CNdelivery：2周
RecommendDilution：WB: 1/2000-1/10000
IHC: 1/20-1/100
ICC/IF: 1/20-1/100
Reactivity：Human
Immunogen：A synthetic phosphopeptide corresponding to residues surrounding Ser952 of human Rb2 p130 (Phosphorylated)
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：RB transcriptional corepressor like 2
Background：Swiss-Prot Acc.Q08999.Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 128 kDa; Observed MW: 130 kDa