RAB7 (RAB7A) Rabbit Monoclonal

ProductName：RAB7 (RAB7A) Rabbit Monoclonal Antibody [Clone ID: R01-3K3]
description：Rab7 Rabbit monoclonal Antibody
symbol：RAB7A
synonyms：FLJ20819; PRO2706; RAB7
locusid：7879
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：P51149
Applications：IHC, WB
CNdelivery：2周
RecommendDilution：WB: 1/1000-1/5000
IHC: 1/20
Reactivity：Human, Mouse
Immunogen：A synthetic peptide of human RAB7
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：RAB7A, member RAS oncogene family
Background：Swiss-Prot Acc.P51149.Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway . Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 24 kDa; Observed MW: 24 kDa