GRP78 (HSPA5) Rabbit Monoclona

ProductName：GRP78 (HSPA5) Rabbit Monoclonal Antibody [Clone ID: R03-5B3]
description：GRP78 BiP Rabbit monoclonal Antibody
symbol：HSPA5
synonyms：BiP; FLJ26106; GRP78; MIF2
locusid：3309
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：P11021
Applications：IHC, WB
CNdelivery：2周
RecommendDilution：WB: 1/1000-1/5000
IHC: 1/50-1/200
Reactivity：Human, Rat
Immunogen：A synthetic peptide of human GRP78 BiP
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：heat shock protein family A (Hsp70) member 5
Background：Swiss-Prot Acc.P11021.Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate . Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 . Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 . Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating.
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 72 kDa; Observed MW: 78 kDa