IRE1 (ERN2) Rabbit Monoclonal

ProductName：IRE1 (ERN2) Rabbit Monoclonal Antibody [Clone ID: R03-3I5]
description：Phospho-IRE1 (Ser724) Rabbit monoclonal Antibody
symbol：ERN1
synonyms：hIRE2p; Ire1-beta; IRE1b; IRE2
locusid：10595
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：O75460
Applications：WB
CNdelivery：2周
RecommendDilution：WB: 1/1000-1/5000
Reactivity：Human
Immunogen：A synthetic phosphopeptide corresponding to residues surrounding Ser724 of human IRE1 (Phosphorylated)
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：endoplasmic reticulum to nucleus signaling 2
Background：Swiss-Prot Acc.O75460.Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262).
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 110 kDa; Observed MW: 110 kDa