EGFR Rabbit Monoclonal Antibod

ProductName：EGFR Rabbit Monoclonal Antibody [Clone ID: R05-2A2]
description：Phospho-EGFR (Tyr1092) Rabbit monoclonal Antibody
symbol：EGFR
synonyms：ERBB; ERBB1; HER1; mENA; PIG61
locusid：1956
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：P00533
Applications：IHC, WB
CNdelivery：2周
RecommendDilution：WB: 1/1000
IHC: 1/50
Reactivity：Human, Mouse, Rat
Immunogen：A synthetic phosphopeptide corresponding to residues surrounding Tyr1092 of human EGFR (Phosphorylated)
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：epidermal growth factor receptor
Background：Swiss-Prot Acc.P00533.Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Plays a role in enhancing learning and memory performance .
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 134 kDa; Observed MW: 175 kDa