CDK4 Rabbit Monoclonal Antibod

ProductName：CDK4 Rabbit Monoclonal Antibody [Clone ID: R04-8I5]
description：CDK4 Rabbit monoclonal Antibody
symbol：CDK4
synonyms：CMM3; MGC14458; PSK-J3
locusid：1019
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：P11802
Applications：IF, IP, WB
CNdelivery：2周
RecommendDilution：WB: 1/1000
ICC/IF: 1/50
IP: 1/20
Reactivity：Human, Mouse
Immunogen：A synthetic peptide of human Cdk4
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：cyclin-dependent kinase 4
Background：Swiss-Prot Acc.P11802.Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 34 kDa; Observed MW: 34 kDa