Caspase 3 (CASP3) Rabbit Monoc

ProductName：Caspase 3 (CASP3) Rabbit Monoclonal Antibody [Clone ID: R04-5C8]
description：Cleaved-Caspase 3 p17 Rabbit monoclonal Antibody
symbol：CASP3
synonyms：apopain; CASP-3; CPP-32; CPP32; CPP32B; procaspase3; SCA-1; Yama
locusid：836
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：P42574
Applications：WB
CNdelivery：2周
RecommendDilution：WB: 1/1000
Reactivity：Mouse, Human, Rat
Immunogen：A synthetic peptide of mouse Caspase-3 (Cleaved)
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：caspase 3
Background：Swiss-Prot Acc.P70677.Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage . Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 32 kDa; Observed MW: 32,17 kDa