Aryl hydrocarbon Receptor (AHR

ProductName：Aryl hydrocarbon Receptor (AHR) Rabbit Monoclonal Antibody [Clone ID: R07-1H9]
description：Aryl Hydrocarbon Receptor Rabbit monoclonal Antibody
symbol：AHR
synonyms：AH-receptor; bHLHe76
locusid：196
Concentration：lot specific
sub_category：Primary Antibodies
uniprot_id：P35869
Applications：WB
CNdelivery：2周
RecommendDilution：WB: 1/1000
Reactivity：Human
Immunogen：A synthetic peptide of human Aryl hydrocarbon Receptor
Purification：Affinity Purified
Conjugation：Unconjugated
ProteinFamilies：null
ProteinPathways：null
GeneName：aryl hydrocarbon receptor
Background：Swiss-Prot Acc.P35869.Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).
Buffer：50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
isotypes_filter：IgG
predicted_size：Calculated MW: 96 kDa; Observed MW: 100 kDa