BioLamina LN111-LN521/MX521/CT

1-A Chemically Defined Hydrogel for Human Liver Organoid Culture

Shicheng Ye 1, Jochem W B Boeter 1, Marko Mihajlovic 2, Frank G van Steenbeek 1, Monique E van Wolferen 1, Loes A Oosterhoff 1, Ary Marsee 1, Massimiliano Caiazzo 3, Luc J W van der Laan 4, Louis C Penning 1, Tina Vermonden 5, Bart Spee 1, Kerstin Schneeberger 1

2-Protocol for automated production of human stem cell derived liver spheres

Jose Meseguer-Ripolles 1, Alvile Kasarinaite 1, Baltasar Lucendo-Villarin 1, David C Hay 1

3-Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures

Tanja Hyvärinen1, Anu Hyysalo1,2, Fikret Emre Kapucu3,4, LauraAarnos1, AndreyVinogradov1, Stephen J. Eglen5, LauraYlä-Outinen1 & Susanna Narkilahti 1*

4-Culturing functional pancreatic islets on α5-laminins and curative transplantation to diabetic mice

Kristmundur Sigmundsson 1, Juha R M Ojala 2, Miina K Öhman 1, Anne-May Österholm 3, Aida Moreno-Moral 1, Anna Domogatskaya 2, Li Yen Chong 1, Yang Sun 1, Xiaoran Chai 1, Joseph A M Steele 4, Benjamin George 1, Manuel Patarroyo 5, Ann-Sofie Nilsson 2, Sergey Rodin 2, Sujoy Ghosh 1, Molly M Stevens 6, Enrico Petretto 1, Karl Tryggvason

5-Laminin 521 Stabilizes the Pluripotency Expression Pattern of Human Embryonic Stem Cells Initially Derived on Feeder Cells

Halima Albalushi 1,2,3, Magdalena Kurek 1,2, Leif Karlsson 2, Luise Landreh 1,2, Kristín Rós Kjartansdóttir 2, Olle Söder 2, Outi Hovatta 4, Jan-Bernd Stukenborg 1,2

人类胚胎干细胞hESC/诱导性多功能干细胞iPSC

[1] Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient. Lotila et al., Stem Cell Research, 2022

[2] Multiple therapeutic effects of human neural stem cells derived from induced pluripotent stem cells in a rat model of post-traumatic syringomyelia. Xu et al., EBio Medicine. 2022

[3] Generation of human induced pluripotent stem cell (iPSC) lines (UUMCBi001-A, UUMCBi002-A) from two healthy donors. Vasylovska et al., Stem Cell Research. 2021

[4] Generation of a bank of clinical-grade, HLA-homozygous iPSC lines with high coverage of the Spanish population. Kuebler et al., Stem Cell Research & Therapy. 2023 

动物干细胞Animal SC

[1] Laminin-511 but Not -332, -111, or -411 Enables Mouse Embryonic Stem Cell Self-Renewal In Vitro. Domogatskaya et al., Stem Cells. 2008

[2] The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Boroviak et al., Nat Cell Biol. 2014 

[3] Enhanced reseeding of decellularized rodent lungs with mouse embryonic stem cells. Lecht et al., Biomaterials. 2013:

神经细胞Neural cells

[1] Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation. Nishimura et al., Stem Cell Reports. 2023

[2] Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP. Zhang et al., Sci Signal. 2017

[3] Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson’s Disease. Kirkeby et al., Cell Stem Cell. 2016

[4] Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease. Kirkeby et al., Clinical and Translational Report. 2023

[5] A protocol for the differentiation of human embryonic stem cells into midbrain dopaminergic neurons. Nishimura et al., STAR Protocols. 2023

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