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文献和实验Collagen-Induced Arthritis as a Model for Rheumatoid Arthritis
Collagen-induced arthritis (CIA) is an animal model of rheumatoid arthritis (RA) that is widely used to address questions of disease pathogenesis and to validate therapeutic targets. Arthritis is normally induced in mice or rats by immunization
Modeling the Effect of Susceptibility Factors (HLA and PTPN22) in Rheumatoid Arthritis
of a causative factor in a genomic region to its identification and the important task of estimating the disease risk due to it. The contrast between cases and controls may be used for the estimation of the genotype relative risks. However, the same population
Tumor Necrosis Factor as a Pharmacological Target
Tumor necrosis factor (TNF) was originally described as a molecule with antitumor properties released by macrophages stimulated with bacterial products. Almost at the same time that TNF was cloned, it was found to be identical to cachectin
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