- 询价
- DIMA BIOTECH/缔码生物
- 武汉
- DMC100276P
- 2025年07月11日
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
Rabbit/Human Fc chimeric IgG1
- 形态：
Liquid
- 保存条件：
Store at 2°C-8°C for 6 months
- 克隆性：
Monoclonal
- 标记物：
PE-conjugated
- 适应物种：
Human
- 保质期：
12个月
- 级别：
仅用于科研
- 库存：
Under Development
- 供应商：
缔码生物（武汉）科技有限公司
- 宿主：
Rabbit
- 靶点：
VEGFA
- 抗体英文名：
PE-conjugated Anti-VEGFA antibody(DMC276); IgG1 Chimeric mAb
- 抗体名：
PE-conjugated Anti-VEGFA antibody(DMC276); IgG1 Chimeric mAb
- 规格：
100test
| SKU | DMC100276P |
|---|---|
| 产品分类 | Monoclonal Antibodies |
| 规格 | Price: 100 test ￥3880.00 |
| 背景 | This gene is a member of the PDGF:VEGF growth factor family. It encodes a heparin-binding protein; which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells; and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome; also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism; and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame; which is located within an internal ribosome entry site. |
| Clone ID | DMC276 |
| 别名 | MVCD1; VEGF; VPF |
| 应用 | Flow Cyt |
| 形态与组成成分 | Liquid，PBS with 0.05% Proclin300, 1% BSA |
| 纯化方式 | Purified from cell culture supernatant by affinity chromatography |
| 反应种属 | Human |
| 推荐稀释比 | Flow Cyt 1:100 |
| 靶点 | VEGFA |
| Uniprot ID | P15692 |
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文献和实验Purification of mAb (IgG) by Chang-Duk Jun, 03/14/2000 Purpose Materials Antibody 7E3 , 2L sup grown in flasks, frozen and thawed overnight. BioRad Affi-Gel Protein A MAPS II Buffers
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
【翻译】Development trends for monoclonal antibody cancer therapeutics
antigens are targeted, the response should ultimately lead to destruction of the targeted cell. The mode of destruction can be direct (for example, via conjugated radioactive isotopes or toxins, or antibody triggered apoptosis) or indirect (for example
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