- 询价
- DIMA BIOTECH/缔码生物
- 武汉
- DMC100741
- 2025年07月13日
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
Rabbit/Human Fc chimeric IgG1
- 形态：
Powder
- 保存条件：
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
Human
- 保质期：
12个月
- 级别：
仅用于科研
- 库存：
In Stock
- 供应商：
缔码生物（武汉）科技有限公司
- 宿主：
Rabbit
- 靶点：
SELPLG
- 抗体英文名：
Anti-SELPLG antibody(68H10), IgG1 Chimeric mAb
- 抗体名：
Anti-SELPLG antibody(68H10), IgG1 Chimeric mAb
- 规格：
50μg
| SKU | DMC100741 |
|---|---|
| 产品分类 | Monoclonal Antibodies |
| 规格 | Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00 |
| 背景 | This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants. |
| Clone ID | 68H10 |
| 别名 | PSGL-1,PSGL1,CD162,Selectin P ligand |
| 应用 | IHC |
| 形态与组成成分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 纯化方式 | Purified from cell culture supernatant by affinity chromatography |
| 反应种属 | Human |
| 推荐稀释比 | IHC 1:100 |
| 靶点 | SELPLG |
| Uniprot ID | A0A7N9CVJ8 |
Figure 1. A. DMC100741 at 10µg/ml staining SELPLG in MM.1S xenografts in nude mice by IHC (SKU# DMC100741);B. DMC100741 at 10µg/ml staining SELPLG in human tonsil tissue by IHC (SKU# DMC100741)
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文献和实验Purification of mAb (IgG) by Chang-Duk Jun, 03/14/2000 Purpose Materials Antibody 7E3 , 2L sup grown in flasks, frozen and thawed overnight. BioRad Affi-Gel Protein A MAPS II Buffers
【翻译】Development trends for monoclonal antibody cancer therapeutics
(ADCC) and complement-dependent cytotoxicity (CDC), respectively, and are mediated through the Fc portion of mAbs. Some mAb isotypes (human IgG1 and IgG3, and murine IgG2a) are potentially more competent than others at inducing ADCC and CDC3, 26, 28
、结果1、MTT法测定结果为了检验嵌合抗CD20Fab’片段对Raji细胞，的生长抑制作用，以PBS为阴性对照，用MTT法测定Fab’片段对Raji细胞生长的影响，其结果显示，Fab’片段对Raji细胞具有抑制作用，其抑制作用具有明显的剂量依赖性，其半数抑制量为（24.2±7.8） µg/ml。表1嵌合抗体CD20 Fab’片段对Raji细胞的生长抑制率Tab 1 The inhibition rate of Raji cells by the anti-CD20 chimeric fragment Fab
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