- 询价
- DIMA BIOTECH/缔码生物
- 武汉
- DMC100225
- 2025年07月12日
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
Rabbit/Human Fc chimeric IgG1
- 形态：
Powder
- 保存条件：
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
Human
- 保质期：
12个月
- 级别：
仅用于科研
- 库存：
In Stock
- 供应商：
缔码生物（武汉）科技有限公司
- 宿主：
Rabbit
- 靶点：
IL21R
- 抗体英文名：
Anti-IL21R antibody(DMC225); IgG1 Chimeric mAb
- 抗体名：
Anti-IL21R antibody(DMC225); IgG1 Chimeric mAb
- 规格：
50μg
| SKU | DMC100225 |
|---|---|
| 产品分类 | Monoclonal Antibodies |
| 规格 | Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00 |
| 背景 | The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors; and has been shown to form a heterodimeric receptor complex with the common gamma-chain; a receptor subunit also shared by the receptors for interleukin 2; 4; 7; 9; and 15. This receptor transduces the growth promoting signal of IL21; and is important for the proliferation and differentiation of T cells; B cells; and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules; including JAK1; JAK3; STAT1; and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. |
| Clone ID | DMC225 |
| 别名 | CD360; IMD56; NILR |
| 应用 | ELISA; Flow Cyt |
| 形态与组成成分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 纯化方式 | Purified from cell culture supernatant by affinity chromatography |
| 反应种属 | Human |
| 推荐稀释比 | ELISA 1:5000-10000; Flow Cyt 1:100 |
| 靶点 | IL21R |
| Uniprot ID | Q9HBE5 |
Figure 1. Flow cytometry analysis with Anti-IL21R (DMC225) on Expi293 cells transfected with human IL21R (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
Figure 2. Flow cytometry analysis of antigen binding of anti-human IL21R mAb(DMC100225). (A) DMC100225 does not bind to 293T cells that do not express IL21R. (B) A clear peak shift of DMC100225 was seen compared to the control when incubated with IL21R-expressing Raji cells, indicating strong binding of DMC100225 to IL21R. Antibodies were incubated at 5 μg/mL.
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文献和实验Purification of mAb (IgG) by Chang-Duk Jun, 03/14/2000 Purpose Materials Antibody 7E3 , 2L sup grown in flasks, frozen and thawed overnight. BioRad Affi-Gel Protein A MAPS II Buffers
【翻译】Development trends for monoclonal antibody cancer therapeutics
(ADCC) and complement-dependent cytotoxicity (CDC), respectively, and are mediated through the Fc portion of mAbs. Some mAb isotypes (human IgG1 and IgG3, and murine IgG2a) are potentially more competent than others at inducing ADCC and CDC3, 26, 28
研究中[8]。（3）MAB528与MAB225MAB528、MAB225是针对EGFR胞外区的鼠源性抗体[9]。它们与EGF、TGFα和EGFR有相似的亲和力，竞争性与EGFR配体结合区结合，减低酪氨酸激酶的活化。能明显抑制培养细胞及裸鼠肿瘤移植物的增殖。（4）其它EMD55900[10]、 ICR62[11]是鼠源性单克隆抗体。在头颈部上皮性肿瘤体外试验显示了抗增生活性。CIBCNSH3[11]也是针对过表达EGFR肿瘤的单克隆抗体。体外实验CIBCNSH3与过表达EGFR细胞共育，发现98%细胞
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