- 询价
- DIMA BIOTECH/缔码生物
- 武汉
- DMC101037
- 2025年07月11日
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
Rabbit/Human Fc chimeric IgG1
- 形态：
Powder
- 保存条件：
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
Human
- 保质期：
12个月
- 级别：
仅用于科研
- 库存：
In Stock
- 供应商：
缔码生物（武汉）科技有限公司
- 宿主：
Rabbit
- 靶点：
TNFRSF1B
- 抗体英文名：
Anti-TNFRSF1B antibody(8C4); IgG1 Chimeric mAb
- 抗体名：
Anti-TNFRSF1B antibody(8C4); IgG1 Chimeric mAb
- 规格：
50μg
| SKU | DMC101037 |
|---|---|
| 产品分类 | Monoclonal Antibodies |
| 规格 | Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00 |
| 背景 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008] |
| Clone ID | 8C4 |
| 别名 | CD120b;p75;p75TNFR;TBPII;TNF-R-II;TNF-R75;TNFBR;TNFR1B;TNFR2;TNFR80 |
| 应用 | Flow Cyt |
| 形态与组成成分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 纯化方式 | Purified from cell culture supernatant by affinity chromatography |
| 反应种属 | Human |
| 推荐稀释比 | Flow Cyt 1/100 |
| 靶点 | TNFRSF1B |
| Uniprot ID | P20333 |
Figure 1. Flow cytometry analysis with Anti-TNFRSF1B (8C4) mAb on Expi293 cells transfected with human TNFRSF1B (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
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文献和实验Purification of mAb (IgG) by Chang-Duk Jun, 03/14/2000 Purpose Materials Antibody 7E3 , 2L sup grown in flasks, frozen and thawed overnight. BioRad Affi-Gel Protein A MAPS II Buffers
【翻译】Development trends for monoclonal antibody cancer therapeutics
(ADCC) and complement-dependent cytotoxicity (CDC), respectively, and are mediated through the Fc portion of mAbs. Some mAb isotypes (human IgG1 and IgG3, and murine IgG2a) are potentially more competent than others at inducing ADCC and CDC3, 26, 28
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