- 询价
- DIMA BIOTECH/缔码生物
- 武汉
- DME100115
- 2025年07月11日
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
Rabbit IgG
- 形态：
Powder
- 保存条件：
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
Human
- 保质期：
12个月
- 级别：
仅用于科研
- 库存：
3~4 weeks
- 供应商：
缔码生物（武汉）科技有限公司
- 宿主：
Rabbit
- 靶点：
TNFRSF10B
- 抗体英文名：
Anti-TNFRSF10B antibody(DM115); Rabbit mAb
- 抗体名：
Anti-TNFRSF10B antibody(DM115); Rabbit mAb
- 规格：
50μg
| SKU | DME100115 |
|---|---|
| 产品分类 | Monoclonal Antibodies |
| 规格 | Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00 |
| 背景 | The protein encoded by this gene is a member of the TNF-receptor superfamily; and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10:TRAIL:APO-2L); and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD; a death domain containing adaptor protein; is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. |
| Clone ID | DM115 |
| 别名 | TNFRSF10B;TRAILR2;TRAIL-R2;CD262;DR5;KILLER;TRICK2;ZTNFR9;TRICKB |
| 应用 | ELISA; Flow Cyt |
| 形态与组成成分 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 纯化方式 | Purified from cell culture supernatant by affinity chromatography |
| 反应种属 | Human |
| 推荐稀释比 | ELISA 1:5000-10000; Flow Cyt 1:100 |
| 靶点 | TNFRSF10B |
| Uniprot ID | O14763 |
Figure 1. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human TNFRSF10B protein, mFc tagged protein PME100465 can bind Rabbit anti-TNFRSF10B monoclonal antibody (clone: DM115) in a linear range of 0.2-70 ng/ml.
Figure 2. TNFRSF10B protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with Anti-TNFRSF10B (DM115) on Expi293 cells transfected with human TNFRSF10B (Blue histogram) or Expi293 transfected with irrelevant protein(Red histogram), and Isotype antibody on Expi293 transfected with irrelevant protein(Orange histogram).
Figure 3. Flow cytometry analysis of antigen binding of rabbit anti-human TNFRSF10B mAb(DME100115). (A) DME100115 does not bind to CHO-S cells that do not express TNFRSF10B. (B) A clear peak shift of DME100115 was seen compared to the control when incubated with TNFRSF10B-expressing SNU-5 cells, indicating strong binding of DME100115 to TNFRSF10B. Antibodies were incubated at 5 μg/mL.
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文献和实验Purification of mAb (IgG) by Chang-Duk Jun, 03/14/2000 Purpose Materials Antibody 7E3 , 2L sup grown in flasks, frozen and thawed overnight. BioRad Affi-Gel Protein A MAPS II Buffers
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antibody unconjugated； 货号21337，产品描述：GAPDH Antibody；规格 50 ul / 100 ul； 货号3052，产品描述：Rabbit anti-Human IgG secondary antibody HRP conjugated； 货号300904050，产品描述：One-Hour Western kit，10 ml / bottle x 3；
【翻译】Development trends for monoclonal antibody cancer therapeutics
, probably owing to their differential affinities for Fc receptors29. It should be noted that chimeric, humanized and human mAbs all have human Fc regions. Of the 115 unmodified mAbs, 97 were full-sized and specific for a single target. mAb fragments
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