聚肌胞/聚肌胞苷酸/聚肌苷酸-聚胞苷酸/聚肌胞甙酸/双链聚肌

中文名称：聚肌胞/聚肌胞苷酸/聚肌苷酸-聚胞苷酸/聚肌胞甙酸/双链聚肌胞/Polyinosinic acid-polycytidylic acid

英文别名：POLY(I:C);POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT;POLYINOSINIC¨CPOLYCYTIDYLIC ACID SODIUM SALT;Polyinosinic Acid.Polycytidylic Acid,Sodium Salt,Double;Poly(I)•Poly(C);Poly(I:C)Poly(I)Poly(C);Polyinosinic Polycytidylic acid sodium salt;[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate;[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate;sodium;[5-(4-Amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate;[3,4-dihydroxy;Polyinosinic-polycytidylic acid sodium;Poly(I;Poly(I:C);Polyinosinic–polycytidylicAcid Sodium Salt;poly C poly I sodium;42424-50-0;GETQKWBYQAUFQM-VRQAYDGLSA-N;G12343

CAS号：42424-50-0

分子式：C19H27N7NaO16P2

分子量：694.39

纯度：BR，90%

生物活性：Polyinosinic-polycytidylicacidsodium(Poly(I:C)sodium)是双链RNA的合成类似物，是一种TLR3和视黄酸诱导型基因I受体(RIG-I和MDA5)的激动剂。Polyinosinic-polycytidylicacidsodium可以用作疫苗佐剂，以增强先天性和适应性免疫反应，并改变肿瘤的微环境，还可以直接触发癌细胞发生凋亡。

体内研究：Polyinosinic-polycytidylicacidtreatmentinhibitstumorgrowthinNOD/SCIDimmunodeficientmiceinjectedwith1205Lucells.ThelevelofhumanDNAis50%lowerinmicetreatedwithPolyinosinic-polycytidylicacid.

用途：一种可作为在TLR3水平对细胞信号转导进行研究的模型RNA的双链均聚物。也是一种TRIF依赖性toll样受体-3(TLR3)配体。