- 询价
- DIMA BIOTECH/缔码生物
- 武汉
- FLP120291
- 2025年09月28日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C to -80°C
- 保质期：
12个月
- 英文名：
Human GPER1-Strep full length protein-synthetic nanodisc
- 库存：
In Stock
- 供应商：
缔码生物（武汉）科技有限公司
- 规格：
10μg
| 货号 | FLP120291 |
|---|---|
| 产品分类 | Full Length Transmembrane Proteins |
| 价格&规格 | Price: 10 μg ￥5670.00 ;50 μg ￥27000.00 ; 100 μg ￥49500.00 |
| 背景 | A multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. |
| 描述 | Human GPER1-Strep full length protein-synthetic nanodisc |
| 分子量 | The human full length GPER1-Strep protein has a MW of 42.2 kDa |
| 蛋白家族 | Druggable Genome, GPCR, Transmembrane |
| 信号通路 | N/A |
| 别名 | CEPR; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER; GPR30; LERGU; LERGU2; LyGPR; mER |
| 标签 | C-Flag&Strep Tag |
| 是否偶联 | Unconjugated |
| 表达宿主 | HEK293 |
| 形式 | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| 靶点 | GPER1 |
| Uniprot ID | Q99527 |
| 用途 | Research use only |
验证图
Figure 1. Elisa plates were pre-coated with C-Flag&Strep Tag GPER1-Strep-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with GPER1-Strep-nanodisc is 5.129ng/ml.
Figure 2. Human GPER1-Strep-Nanodisc, C-Flag&Strep Tag on SDS-PAGE
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验三句话读懂一篇 CNS：晚睡晚起导致抑郁；吃药代替运动健身；高脂肪饮食引发结直肠癌...
结构 研究表明 LRRK2 蛋白酶突变是导致帕金森病的关键原因之一。 2021 年 6 月 8 日，圣裘德儿童研究医院孙吉教授团队在 Cell 上发表研究论文 Structural analysis of the full-length human LRRK2，该研究首次解析了人类 LRRK2 全长蛋白的高分辨率结构，为人类战胜帕金森病提供了理论参考。图 6：来源 Cell 7. Lacent: 父母学历越高，所生小孩死亡率越低 2021 年 6 月 10 日，挪威科技大学 Terje
receptor8. Mouse apoB is a large protein of 4,515 amino acids and is expressed predominantly in liver and jejunum. apoB mRNA is subject to post-transcriptional editing, and the unedited and edited transcripts encode the full-length protein apoB-100
位点，RNA聚合酶在此和DNA结合，并由此开始转录过程。 蛋白质（Protein）：一种由一条或者多条肽链构成的大分子。每条肽链上核苷酸的顺序是由基因外显子部分的碱基序列决定的。蛋白质是细胞、组织和器官的重要组成部分，每种蛋白质都具有特定的功能。酶、抗体和激素等都是蛋白质。 嘌呤（Purine）：一种含氮的单环结构物。是核苷酸的重要组成部分，有腺嘌呤A和鸟嘌呤G两种。 嘧啶（Pyrimidine）：一种含氮的双环结构，是核苷酸的重要组成部分。分为胞嘧啶C，胸腺嘧啶T和尿嘧啶U三种
技术资料暂无技术资料 索取技术资料
