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- DIMA BIOTECH/缔码生物
- 武汉
- FLP100009
- 2025年07月15日
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- 保存条件：
-20°C to -80°C
- 保质期：
12个月
- 英文名：
Human CB1 full length protein-MNP
- 库存：
In Stock
- 供应商：
缔码生物（武汉）科技有限公司
- 规格：
50μg
| 货号 | FLP100009 |
|---|---|
| 产品分类 | Full Length Transmembrane Proteins |
| 价格&规格 | Price: 50 μg ￥8000.00 ; 100 μg ￥10800.00 |
| 背景 | The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. |
| 描述 | Human CB1 full length protein membrane nanoparticles (MNPs) |
| 分子量 | The human full length CB1 Protein has a MW of 52.7 kDa |
| 蛋白家族 | GPCR |
| 信号通路 | Neuroactive ligand-receptor interaction |
| 别名 | CANN6; CB-R; CNR1; CB1A; CB1K5; CB1R; CNR |
| 标签 | N/A |
| 是否偶联 | Unconjugated |
| 表达宿主 | HEK293 |
| 形式 | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| 靶点 | CB1 |
| Uniprot ID | P21554 |
| 用途 | Research use only |
验证图
Figure1. Elisa plates were pre-coated with 0.5μg/per well purified human CB1 full length membrane nanoparticles. Serial diluted anti-CB1 monoclonal antibody (DME100144) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-CB1 monoclonal antibody binding with CB1 full length membrane nanoparticles is 439.6ng/ml. 
Figure2. FACS analysis of CB1 MNPs A. Negative Control 1: CB1 full length membrane nanoparticles samples were stained only with Goat anti-human lgG 488 secondary antibody. B. Negative Control 2: Control membrane nanoparticles samples were stained with anti-CB1 antibody (BME100049) at 2μg/mL, followed by Goat anti-human IgG 488 secondary antibody. C. Negative Control 3: CB1 full length membrane nanoparticles samples were stained with anti-CCR8 antibody (an irrelevant antibody) at 2μg/mL, followed by Goat anti-human IgG 488 secondary antibody. D. CB1 full length membrane nanoparticles samples were stained with anti-CB1 antibody (BME100049) at 2μg/mL, followed by Goat anti-human IgG 488 secondary antibody.
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