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- AntibodySystem
- DHC12519
- France
- 2025年07月15日
- Research Grade Biosimilar
- Human
- Human
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- 文献和实验
- 技术资料
- 抗体名：
Research Grade Anti-Human APP/Amyloid beta (AD0802)
- 抗体英文名：
Research Grade Anti-Human APP/Amyloid beta (AD0802)
- 浓度：
1 mg/ml
- 应用范围：
Research Grade Biosimilar
- 宿主：
Human
- 适应物种：
Human
- 保质期：
1 year
- 级别：
科研级
- 库存：
999
- 供应商：
AntibodySystem
- 克隆性：
Monoclonal
- 保存条件：
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- 形态：
Liquid
- 亚型：
IgG
- 规格：
100ug
| 宿主 | Human |
| 种属反应性 | Human |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. |
| 浓度 | 1 mg/ml |
| 纯度 | >95% as determined by SDS-PAGE. |
| 克隆类型 | Monoclonal |
| 同种型 | IgG |
| 应用 | Research Grade Biosimilar |
| 靶标 | AICD-57, A4, Beta-CTF, Protease nexin-II, Gamma-CTF(50), ABPP, S-APP-beta, APP, Abeta40, Abeta42, AID(59), Amyloid intracellular domain 59, AID(57), S-APP-alpha, Gamma-CTF(59), Beta-secretase C-terminal fragment, Amyloid-beta precursor protein, Amyloid precursor protein, Beta-APP42, PreA4, Alzheimer disease amyloid protein, APPI, PN-II, AICD-59, Alpha-secretase C-terminal fragment, Amyloid-beta A4 protein, Amyloid intracellular domain 57, CVAP, Amyloid intracellular domain 50, Beta-APP40, AD1, Cerebral vascular amyloid peptide, AID(50), Alpha-CTF, Gamma-CTF(57), AICD-50 |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | Please contact with the lab for this information. |
| 表达系统 | Mammalian Cells |
| Accession号 | P05067 |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 别名 | AD0802 |
| 克隆号 | AD0802 |
| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
AntibodySystem's product range supports research in multiple fields, encompassing 48 types of viruses, superbugs, parasites, oncology, Alzheimer's, Parkinson's, hypersensitivity, immune suppression, and immune activation.
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文献和实验Using an Amyloid Precursor Protein (APP) Reporter to Characterize α-Secretase
Human genetic studies suggest decreasing amyloid peptide (Aβ) levels in the brain could alter the course of Alzheimer’s disease (AD) (1 -4 ). Proteolytic cleavages govern the level of Aβ generated from the amyloid precursor protein (APP). β
结构部分由 E1 和 E2 两个亚结构域组成，胞质内区域称为 E3 结构域 ［2］。 图片来源于：Coburger I et al．Analysis of the overall structure of the multi-domain amyloid precursor protein (APP) Aβ是由 APP 编码的蛋白经一系列水解酶酶切产生（学霸自行跳过文字，看图脑补即可）。APP 在跨膜分泌过程中共有 2 条水解途径，即不产生 AD 的非淀粉
/Amyloid__beta_-Peptide__1-42__human.html 诱导Aβ 蛋白沉积、记忆障碍、突触功能障碍和神经发生受损 Scopolamine (HY-N0296) www.medchemexpress.cn/Scopolamine.html 诱导动物认知记忆缺陷 beta-Amyloid抗体(YA6114)(HY-P86422) www.medchemexpress.cn/antibody/amyloid-%CE%B2-antibody-ya6114.html 抗 Amyloid-β
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