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- 详细信息
- 技术资料
- 库存:
999
- 供应商:
AntibodySystem
- 检测范围:
0.31-5 μg/mL
- 检测方法:
Colorimetric
- 应用:
ELISA
- 标记物:
HRP
- 样本:
Plasma, Serum
- 灵敏度:
0.156 μg/ml
- 规格:
96T

| 稳定性和存储 | The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition. |
| 检测方法 | Colorimetric |
| 精准度 |
CV<20% |
| 样本类型 | Plasma, Serum |
| 实验类型 | Quantitative |
| 灵敏度 | 0.156 μg/ml |
| 检测范围 | 0.31-5 μg/mL |
| 回收率 | 80-120% |
| 背景 | Codrituzumab is a humanized monoclonal antibody targeted at glypican-3 (GPC3), which is a member of the glypican family. This drug is developed by Chugai Pharmaceutical in combination with Roche and has been investigated in the treatment of liver cancer. The specific expression of GPC3 is high in hepatocellular carcinoma (HCC) tissues, which suggests that GPC3 has obvious sensitivity and specificity in the diagnosis of hepatocellular carcinoma, and can be used as a new target for the treatment of hepatocellular carcinoma. Codrituzumab did not show significant inhibition of GPC3 in the phase I trial in combined with sorafenib and the phase II trial placebo-controlled study in patients with advanced liver cancer. Codrituzumab did not show significant inhibition of GPC3 in phase I trials and phase II trials combined with sorafenib in patients with advanced liver cancer. However, the effect of codrituzumab in the treatment of liver cancer is still under study. In 2018, researchers conducted trials such as the distribution of codrituzumab and the impact of overall survival in patients with hepatocellular carcinoma. In the combined analysis of tumor cell surface antigen GPC3 and NK cell surface antigen CD16 in patients with liver cancer, it was found that codrituzumab only had a certain therapeutic effect on patients with high expression level of GPC3 and CD16. These results suggest that GPC3 and CD16 can be used as a composite biomarker to select hepatocellular carcinoma patients for codrituzuma. |
| 别名 | GC33, RG7686, RO5137382, CAS: 1365267-33-9 |
| 运输 | 2-8 ℃ |
| 备注 | For Research Use Only. |
Established in 2019 in France, AntibodySystem Laboratories SAS is a standalone brand dedicated to the production of protein and antibody reagents for life science research. We aim to empower researchers globally with high-quality products for fundamental scientific research. AntibodySystem offers a broad selection, including traditional polyclonal antibodies, essential housekeeping antibodies, tag antibodies, high-potency proteins, functional antibodies for in vivo use, low-background flow antibodies, highly specific nanobodies, unique small molecule antibodies, high-quality phospho-specific antibodies, DNA/RNA antibodies, and PEG antibodies, among others.
AntibodySystem's product range supports research in multiple fields, encompassing 48 types of viruses, superbugs, parasites, oncology, Alzheimer's, Parkinson's, hypersensitivity, immune suppression, and immune activation.
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