M07e细胞

M-07e、M-07e、M-07e细胞、M-07e细胞、M-07e人巨细胞白血病细胞

Cell line name M-07e

Synonyms M-07E; M-O7e; M07-e; M07e; Mo7e; MO7e; M07E; MO7E

Accession CVCL_2106

Resource Identification Initiative To cite this cell line use: M-07e (RRID:CVCL_2106)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: LL-100 blood cancer cell line panel.

Population: Caucasian.

Doubling time: 46 +- 12 hours (PubMed=9096695); ~40 hours (DSMZ=ACC-104).

Omics: Deep exome analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Sequence variations

Gene fusion; HGNC; 31677; ANO7 + HGNC; 17887; DHDH; Name(s)=ANO7-DHDH (PubMed=31160637).

Gene fusion; HGNC; 1537; CBFA2T3 + HGNC; 29450; GLIS2; Name(s)=CBFA2T3-GLIS2, ETO2-GLIS2 (PubMed=28109323).

Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (DepMap=ACH-000602).

HLA typing Source: DSMZCellDive=ACC-104

Class I

HLA-A A*24:02:01,66:01:01

HLA-B B*13:02:01,49:01:01

HLA-C C*06:02:01;07:01:01

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 8.96

Native American 0

East Asian, North 0.92

East Asian, South 0

South Asian 3.01

European, North 45.47

European, South 41.63

Disease Childhood acute megakaryoblastic leukemia (NCIt: C7972)

Acute megakaryoblastic leukemia (ORDO: Orphanet_518)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy Parent: CVCL_D630 (M-07)

Children:

CVCL_RM07 (M-07e/TPO)

Sex of cell Female

Age at sampling 6M

Category Cancer cell line

STR profile Source(s): CCRID=1101HUM-PUMC000112; DSMZ=ACC-104

 

Markers:

Amelogenin X

CSF1PO 9,10

D2S1338 19,25

D3S1358 16,19

D5S818 11

D7S820 11

D8S1179 13 (DSMZ=ACC-104)

13,16 (CCRID=1101HUM-PUMC000112)

D13S317 10,11

D16S539 11

D18S51 15,20

D19S433 14,15

D21S11 30,32.2

FGA 18,22

Penta D 9

Penta E 12,14

TH01 6,8

TPOX 8

vWA 16,18

 

Run an STR similarity search on this cell line

PubMed=2273055; DOI=10.1002/jcp.1041450310

Avanzi G.C., Brizzi M.F., Giannotti J., Brennan A., Yang Y.-C., Pegoraro L., Clark S.C.

M-07e human leukemic factor-dependent cell line provides a rapid and sensitive bioassay for the human cytokines GM-CSF and IL-3.

J. Cell. Physiol. 145:458-464(1990)

 

PubMed=9096695; DOI=10.1038/sj.leu.2400621

Drexler H.G., Zaborski M., Quentmeier H.

Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines.

Leukemia 11:541-551(1997)

 

DOI=10.1016/B978-0-12-221970-2.50457-5

Drexler H.G.

The leukemia-lymphoma cell line factsbook.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

 

PubMed=11414198; DOI=10.1007/s004320000207

Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.-J.

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.

J. Cancer Res. Clin. Oncol. 127:375-386(2001)

 

PubMed=16408098; DOI=10.1038/sj.leu.2404081

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Leukemia 20:471-476(2006)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)

 

PubMed=28109323; DOI=10.1186/s13045-017-0396-0; PMCID=PMC5251306

Masetti R., Bertuccio S.N., Astolfi A., Chiarini F., Lonetti A., Indio V., De Luca M., Bandini J., Serravalle S., Franzoni M., Pigazzi M., Martelli A.M., Basso G., Locatelli F., Pession A.

Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene.

J. Hematol. Oncol. 10:26.1-26.5(2017)

 

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786

Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H.H., Koeffler H.P.

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

BMC Cancer 18:940.1-940.13(2018)

 

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

Screening human cell lines for viral infections applying RNA-Seq data analysis.

PLoS ONE 14:E0210404-E0210404(2019)

 

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)

 

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103

Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Nature 569:503-508(2019)

 

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646

Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.

The LL-100 panel: 100 cell lines for blood cancer studies.

Sci. Rep. 9:8218-8218(2019)