IM9细胞

IM-9、IM-9、IM-9细胞、IM-9细胞、IM-9人外周血B淋巴瘤细胞

Cell line name IM-9

Synonyms IM 9; IM9; GM04680

Accession CVCL_1305

Resource Identification Initiative To cite this cell line use: IM-9 (RRID:CVCL_1305)

Comments Problematic cell line: Misclassified. Originally thought to be a myeloma cell line but is a B-lymphoblastoid cell line (PubMed=10516762).

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Population: Caucasian.

Doubling time: ~45 hours (DSMZ=ACC-117); ~1 day (Note=Lot 09172008), ~23 hours (Note=Lot 03302009) (JCRB=JCRB0024).

Microsatellite instability: Stable (MSS) (Sanger).

Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).

Omics: CRISPR phenotypic screen.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.

Sequence variations

Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (Cosmic-CLP=753563; DepMap=ACH-002247).

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 0

Native American 0.41

East Asian, North 0

East Asian, South 0

South Asian 0

European, North 68.16

European, South 31.43

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy Children:

CVCL_B6CV (IM-9-P)

Sex of cell Female

Age at sampling Age unspecified

Category Transformed cell line

STR profile Source(s): ATCC=CCL-159; CCRID=1102HUM-NIFDC00064; Cosmic-CLP=753563; DSMZ=ACC-117; JCRB=JCRB0024; KCLB=10159

 

Markers:

Amelogenin X

CSF1PO 10,11

D2S1338 24,26

D3S1358 14,18

D5S818 13

D7S820 11,12

D8S1179 12,13

D13S317 9,11

D16S539 9,13

D18S51 14,17

D19S433 13,14

D21S11 30,30.2

FGA 20,23

Penta D 9,11

Penta E 13,15

TH01 6,9.3

TPOX 11

vWA 14,17

 

Run an STR similarity search on this cell line

Publications

PubMed=2836165; DOI=10.1210/endo-122-6-2508

DiMattia G.E., Gellersen B., Bohnet H.G., Friesen H.G.

A human B-lymphoblastoid cell line produces prolactin.

Endocrinology 122:2508-2517(1988)

 

PubMed=1366653; DOI=10.1007/BF00365265

Bonhoff A., Gellersen B., Held K.R., Bohnet H.G.

Clonal derivatives of a human B-lymphoblastoid cell line producing prolactin -- a cytogenetic characterization.

Cytotechnology 3:43-50(1990)

 

CLPUB00447

Mulivor R.A., Suchy S.F.

1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.

(In misc. document) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda; USA (1992)

 

PubMed=8139288; DOI=10.1016/0145-2126(94)90118-x

Sato S., Honma Y., Hozumi M., Hayashi Y., Matsuo Y., Shibata K., Omura S., Hino K.-i., Tomoyasu S., Tsuruoka N.

Effects of herbimycin A and its derivatives on growth and differentiation of Ph1-positive acute lymphoid leukemia cell lines.

Leuk. Res. 18:221-228(1994)

 

PubMed=7579375; DOI=10.1182/blood.V86.10.4001.bloodjournal86104001

Pellat-Deceunynck C., Amiot M., Bataille R., Van Riet I., Van Camp B., Omede P., Boccadoro M.

Human myeloma cell lines as a tool for studying the biology of multiple myeloma: a reappraisal 18 years after.

Blood 86:4001-4002(1995)

 

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D

Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Screening the p53 status of human cell lines using a yeast functional assay.

Mol. Carcinog. 19:243-253(1997)

 

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588

Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H.

Frameshift mutations of the hMSH6 gene in human leukemia cell lines.

Jpn. J. Cancer Res. 89:33-39(1998)

 

PubMed=10516762; DOI=10.1038/sj.leu.2401510

Drexler H.G., Dirks W.G., MacLeod R.A.F.

False human hematopoietic cell lines: cross-contaminations and misinterpretations.

Leukemia 13:1601-1607(1999)

 

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2

Drexler H.G., Matsuo Y.

Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.

Leuk. Res. 24:681-703(2000)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168

Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.

Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.

J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

 

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469

Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Miroo T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

A landscape of pharmacogenomic interactions in cancer.

Cell 166:740-754(2016)

 

PubMed=29892436; DOI=10.1098/rsos.172472; PMCID=PMC5990783

Shioda S., Kasai F., Watanabe K., Kawakami K., Ohtani A., Iemura M., Ozawa M., Arakawa A., Hirayama N., Kawaguchi E., Tano T., Miyata S., Satoh M., Shimizu N., Kohara A.

Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection.

R. Soc. Open Sci. 5:172472-172472(2018)

 

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)