Li7细胞

Li-7/Li-7细胞系/Li-7细胞株/Li-7人肝癌细胞；

Cell line name Li-7

Synonyms LI7; Li7; C-Li-7

Accession CVCL_3840

Resource Identification Initiative To cite this cell line use: Li-7 (RRID:CVCL_3840)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: JFCR45 cancer cell line panel.

Part of: Liver Cancer Model Repository (LIMORE).

Population: Japanese.

Omics: Deep exome analysis.

Omics: Genome sequenced.

Omics: miRNA expression profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Liver; UBERON=UBERON_0002107.

Sequence variations

Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31378681).

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 0

Native American 0.93

East Asian, North 80.68

East Asian, South 17.95

South Asian 0

European, North 0.44

European, South 0

Disease Adult hepatocellular carcinoma (NCIt: C7956)

Adult hepatocellular carcinoma (ORDO: Orphanet_210159)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy Children:

CVCL_XE71 (Li-7-Cas9-751) CVCL_XE72 (Li-7-Cas9-752) CVCL_XE73 (Li-7-Cas9-753)

CVCL_XE74 (Li-7-Cas9-754) CVCL_XE75 (Li-7-Cas9-755) CVCL_XE76 (Li-7-Cas9-756)

CVCL_XE77 (Li-7-Cas9-757) CVCL_XE78 (Li-7-Cas9-758) CVCL_XE79 (Li-7-Cas9-759)

CVCL_XE80 (Li-7-Cas9-760) CVCL_XE70 (Li-7-Luc2-tdT)

Sex of cell Male

Age at sampling 45Y

Category Cancer cell line

STR profile Source(s): CCRID; PubMed=25877200; PubMed=31378681; RCB=RCB1941; TKG=TKG 0368

 

Markers:

Amelogenin X

CSF1PO 12

D2S1338 17,19

D3S1358 15,16

D5S818 9,11

D7S820 10,11

D8S1179 13,14

D13S317 11

D16S539 9

D18S51 16

D19S433 12,14

D21S11 30

FGA 20

Penta D 10

Penta E 5

TH01 7

TPOX 8 (TKG=TKG 0368)

8,11 (CCRID; PubMed=25877200; PubMed=31378681; RCB=RCB1941)

vWA 16,19

 

Run an STR similarity search on this cell line

Publications

PubMed=85491

Hirohashi S., Shimosato Y., Kameya T., Koide T., Mukojima T., Taguchi Y., Kageyama K.

Production of alpha-fetoprotein and normal serum proteins by xenotransplanted human hepatomas in relation to their growth and morphology.

Cancer Res. 39:1819-1828(1979)

 

PubMed=2542205; DOI=10.1111/j.1349-7006.1989.tb02290.x; PMCID=PMC5917712

Tsuda H., Hirohashi S., Shimosato Y., Ino Y., Yoshida T., Terada M.

Low incidence of point mutation of c-Ki-ras and N-ras oncogenes in human hepatocellular carcinoma.

Jpn. J. Cancer Res. 80:196-199(1989)

 

PubMed=12029633; DOI=10.1053/jhep.2002.33683

Yasui K., Arii S., Zhao C., Imoto I., Ueda M., Nagai H., Emi M., Inazawa J.

TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas.

Hepatology 35:1476-1484(2002)

 

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234

Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., Yamori T.

Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.

Mol. Cancer Ther. 4:399-412(2005)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)

 

PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665

Nault J.-C., Mallet M., Pilati C., Calderaro J., Bioulac-Sage P., Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J.

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.

Nat. Commun. 4:2218.1-2218.7(2013)

 

PubMed=25877200; DOI=10.1038/nature14397

Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.

A resource for cell line authentication, annotation and quality control.

Nature 520:307-311(2015)

 

PubMed=30784169; DOI=10.1111/cas.13978; PMCID=PMC6500967

Sato Y., Yamada T., Hiroyama T., Sudo K., Hasegawa N., Hyodo I., Nakamura Y.

A robust culture method for maintaining tumorigenic cancer stem cells in the hepatocellular carcinoma cell line Li-7.

Cancer Sci. 110:1644-1652(2019)

 

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)

 

PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001

Caruso S., Calatayud A.-L., Pilet J., La Bella T., Rekik S., Imbeaud S., Letouze E., Meunier L., Bayard Q., Rohr-Udilova N., Peneau C., Grasl-Kraupp B., de Koning L., Ouine B., Bioulac-Sage P., Couchy G., Calderaro J., Nault J.-C., Zucman-Rossi J., Rebouissou S.

Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.

Gastroenterology 157:760-776(2019)