NCIH446细胞

NCI-H446/NCI-H446细胞系/NCI-H446细胞株/NCI-H446人小细胞肺癌细胞

Cell line name NCI-H446

Synonyms H446; H-446; NCI-446; NCIH446

Accession CVCL_1562

Resource Identification Initiative To cite this cell line use: NCI-H446 (RRID:CVCL_1562)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: MD Anderson Cell Lines Project.

Part of: MYC genetic alteration cell panel (ATCC TCP-1035).

Population: Caucasian.

Karyotypic information: Hypertriploid karyotype.

Microsatellite instability: Stable (MSS) (Sanger).

Omics: Deep exome analysis.

Omics: Deep proteome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: miRNA expression profiling.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Misspelling: NCI-H4466; Cosmic=2668272; Note=Prior to 2020.

Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.

PubMed=8806103; DOI=10.1002/jcb.240630516

Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M., Ihde D.C., Gazdar A.F.

MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.

J. Cell. Biochem. Suppl. 24:210-217(1996)

 

PubMed=11030152; DOI=10.1038/sj.onc.1203815

Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.

Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.

Oncogene 19:4632-4639(2000)

 

CLPUB00716

Zhang H.-J., Yan Y.-L., Zheng L.-F., Wan P.

Establishment and characterization of an etoposide-resistant human small cell lung cancer cell line H446/VP.

Zhong Liu 24:233-236(2004)

 

PubMed=16677475; DOI=10.3760/j:issn:1001-0939.2006.03.005

Ji F.-Y., Qian G.-S., Qian P., Chen Y., Guo R.-L., Li S.-P., Huang G.-J.

Involvement of bcl-2 in multidrug resistance in human small cell lung cancer cell subline H446/DDP.

Zhonghua Jie He He Hu Xi Za Zhi 29:156-160(2006)

 

PubMed=17426248; DOI=10.1158/1541-7786.MCR-06-0367

Olejniczak E.T., Van Sant C., Anderson M.G., Wang G., Tahir S.K., Sauter G., Lesniewski R., Semizarov D.

Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.

Mol. Cancer Res. 5:331-339(2007)

 

PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846

Blanco R., Iwakawa R., Tang M.-Y., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.

A gene-alteration profile of human lung cancer cell lines.

Hum. Mutat. 30:1199-1206(2009)

 

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113

Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Signatures of mutation and selection in the cancer genome.

Nature 463:893-898(2010)

 

PubMed=20193106; DOI=10.5732/cjc.009.10330

Wang B., Yang H., Huang Y.-Z., Yan R.-H., Liu F.-J., Zhang J.-N.

Biologic characteristics of the side population of human small cell lung cancer cell line H446.

Chin. J. Cancer 29:254-260(2010)

 

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662

Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Cancer Res. 70:2158-2164(2010)

 

PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680

Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.

Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.

Cancer Sci. 101:1891-1896(2010)

 

PubMed=21163134; DOI=10.3760/cma.j.issn.0366-6999.2010.22.024

Wang Y.-L., Yan Y.-L., Zhou N.-J., Han S., Zhao J.-X., Cao C.-L., Lu Y.-H.

Mechanism of multidrug resistance of human small cell lung cancer cell line H446/VP.

Chin. Med. J. 123:3299-3303(2010)