ins1细胞

INS-1/INS-1细胞系/INS-1细胞株/INS-1大鼠胰岛细胞瘤细胞

Cell line name INS-1

Synonyms INS1

Accession CVCL_0352

Resource Identification Initiative To cite this cell line use: INS-1 (RRID:CVCL_0352)

Comments Characteristics: Established from the transplantable insulinoma RIN.

Transformant: NCIt; C17262; X-Ray.

Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.

Cell type: Pancreatic beta cell; CL=CL_0000169.

Disease Rat insulinoma (NCIt: C121566)

Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)

Breed/subspecies: NEDH; RS=RS:0000603.

Hierarchy Children:

CVCL_WH61 (GRINCH) CVCL_E1LG (HyCyte INS-1 KO-rHnf1a) CVCL_E1LH (HyCyte INS-1 KO-rHnf4a)

CVCL_E1LI (HyCyte INS-1 KO-rIer3ip1) CVCL_E1LJ (HyCyte INS-1 KO-rSsr1) CVCL_EG57 (INS-1 832/1)

CVCL_7226 (INS-1 832/13) CVCL_EG56 (INS-1 832/2) CVCL_ZL55 (INS-1 832/3)

CVCL_2G79 (INS-1 833/117) CVCL_2G78 (INS-1 833/15) CVCL_2G77 (INS-1 834/40)

CVCL_0351 (INS-1E) CVCL_W945 (INS-r3)

Originate from same individual CVCL_J993 ! INS-2

CVCL_3584 ! RIN-m

CVCL_D163 ! RIN-r

Sex of cell Male

Age at sampling 666D

Category Cancer cell line

Publications

PubMed=1370150; DOI=10.1210/endo.130.1.1370150

Asfari M., Janjic D., Meda P., Li G.-D., Halban P.A., Wollheim C.B.

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

Endocrinology 130:167-178(1992)

 

PubMed=8697299

Poitout V., Olson L.K., Robertson R.P.

Insulin-secreting cell lines: classification, characteristics and potential applications.

Diabetes Metab. 22:7-14(1996)

 

PubMed=22538498; DOI=10.1159/000338793

Grozinsky-Glasberg S., Shimon I., Rubinfeld H.

The role of cell lines in the study of neuroendocrine tumors.

Neuroendocrinology 96:173-187(2012)

 

PubMed=36180704; DOI=10.1007/978-1-0716-2593-4_35

Zibolka J., Bahr I., Peschke E., Muhlbauer E., Bazwinsky-Wutschke I.

Human and rodent cell lines as models of functional melatonin-responsive pancreatic islet cells.

Methods Mol. Biol. 2550:329-352(2022)