Mino人套细胞淋巴瘤细胞

Mino/Mino细胞系/Mino细胞株/Mino人外周血套细胞淋巴瘤细胞

Cell line name Mino

Synonyms MINO

Accession CVCL_1872

Resource Identification Initiative To cite this cell line use: Mino (RRID:CVCL_1872)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: LL-100 blood cancer cell line panel.

Part of: Lymphoma Research Foundation Mantle Cell Lymphoma cell bank (LRF MCL cell bank).

Part of: MD Anderson Cell Lines Project.

Population: Caucasian.

Doubling time: 72 hours (PubMed=25315077); ~50 hours (DSMZ=ACC-687).

Omics: Deep exome analysis.

Omics: DNA methylation analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Omics: Virome analysis using RNAseq.

Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.

Sequence variations

Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu88Lys (c.262G>A); ClinVar=VCV000821566; Zygosity=Homozygous (DepMap=ACH-000220).

Mutation; HGNC; 7989; NRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000013901; Zygosity=Heterozygous (DepMap=ACH-000220).

Mutation; HGNC; 11998; TP53; Simple; p.Val147Gly (c.440T>G); Zygosity=Homozygous (DepMap=ACH-000220).

HLA typing Source: PubMed=25960936

Class I

HLA-A A*11:01,68:01

HLA-B B*35:01,39:01

HLA-C C*04:01,12:03

Class II

HLA-DQ DQA1*01:02,01:02

DQB1*05:01,06:03

HLA-DR DRB1*01:01,13:01

 

Source: PubMed=25688540

Class I

HLA-A A*11,68

HLA-B B*35,39

HLA-C C*04,12

 

Source: DSMZCellDive=ACC-687

Class I

HLA-A A*11:01:01,68:01:01

HLA-B B*35:01:01,39:01:01

HLA-C C*04:01:01,12:03:01

Class II

HLA-DP DPA1*01:03:01,02:01:01

DPB1*10:01:01,10:01:01

HLA-DQ DQA1*01:03:01,01:01:01

DQB1*05:01:01,06:03:01

HLA-DR DRA*01:01:01,01:02:02

DRB1*01:01:01,13:01:01

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 0.85

Native American 0

East Asian, North 1.5

East Asian, South 0

South Asian 6.1

European, North 39.56

European, South 51.98

Disease Mantle cell lymphoma (NCIt: C4337)

Mantle cell lymphoma (ORDO: Orphanet_52416)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell Male

Age at sampling 68Y

Category Cancer cell line

STR profile Source(s): AddexBio=C0003033/4947; ATCC=CRL-3000; DSMZ=ACC-687

 

Markers:

Amelogenin X,Y

CSF1PO 9,11

D2S1338 23

D3S1358 18

D5S818 11,12

D7S820 10,11

D8S1179 13

D13S317 12

D16S539 11,12

D18S51 12,14

D19S433 15

D21S11 29,30

FGA 23,25

Penta D 12,13

Penta E 5,17

TH01 9.3

TPOX 8,11

vWA 14,17

 

Run an STR similarity search on this cell line

Publications

PubMed=12127561; DOI=10.1016/S0145-2126(02)00013-9

Lai R., McDonnell T.J., O'Connor S.L., Medeiros L.J., Oudat R.I., Keating M.J., Morgan M.B., Curiel T.J., Ford R.J. Jr.

Establishment and characterization of a new mantle cell lymphoma cell line, Mino.

Leuk. Res. 26:849-855(2002)

 

PubMed=12683869; DOI=10.5858/2003-127-0424-COMCLC

Amin H.M., McDonnell T.J., Medeiros L.J., Rassidakis G.Z., Leventaki V., O'Connor S.L., Keating M.J., Lai R.

Characterization of 4 mantle cell lymphoma cell lines. Establishment of an in vitro study model.

Arch. Pathol. Lab. Med. 127:424-431(2003)

 

PubMed=21746927; DOI=10.1073/pnas.1018941108; PMCID=PMC3145731

Beltran E., Fresquet V., Martinez-Useros J., Richter-Larrea J.A., Sagardoy A., Sesma I., Almada L.L., Montes-Moreno S., Siebert R., Gesk S., Calasanz M.J., Malumbres R., Rieger M., Prosper F., Lossos I.S., Piris M.A., Fernandez-Zapico M.E., Martinez-Climent J.A.

A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.

Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)

 

PubMed=24362935; DOI=10.1038/nm.3435

Rahal R., Frick M., Romero R., Korn J.M., Kridel R., Chan F.C., Meissner B., Bhang H.-E.C., Ruddy D., Kauffmann A., Farsidjani A., Derti A., Rakiec D., Naylor T., Pfister E., Kovats S., Kim S., Dietze K., Dorken B., Steidl C., Tzankov A., Hummel M., Monahan J.E., Morrissey M.P., Fritsch C., Sellers W.R., Cooke V.G., Gascoyne R.D., Lenz G., Stegmeier F.

Pharmacological and genomic profiling identifies NF-kappaB-targeted treatment strategies for mantle cell lymphoma.

Nat. Med. 20:87-92(2014)

 

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

OncoImmunology 3:e954893.1-e954893.12(2014)

 

PubMed=25315077; DOI=10.3109/10428194.2014.970548

Fogli L.K., Williams M.E., Connors J.M., Reid Y.A., Brown K., O'Connor O.A.

Development and characterization of a Mantle Cell Lymphoma Cell Bank in the American Type Culture Collection.

Leuk. Lymphoma 56:2114-2122(2015)

 

PubMed=25355872; DOI=10.1128/JVI.02570-14; PMCID=PMC4301145

Cao S.-B., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z., O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.

High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.

J. Virol. 89:713-729(2015)

 

PubMed=25688540; DOI=10.1002/cyto.a.22643

Maiga S., Brosseau C., Descamps G., Dousset C., Gomez-Bougie P., Chiron D., Menoret E., Kervoelen C., Vie H., Cesbron A., Moreau-Aubry A., Amiot M., Pellat-Deceunynck C.

A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines.

Cytometry A 87:285-288(2015)

 

PubMed=26194763; DOI=10.1182/blood-2015-01-624585; PMCID=PMC4582332

Bhatt S., Matthews J., Parvin S., Sarosiek K.A., Zhao D.-K., Jiang X.-Y., Isik E., Letai A.G., Lossos I.S.

Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.

Blood 126:1555-1564(2015)

 

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076

Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.

Characterization of human cancer cell lines by reverse-phase protein arrays.

Cancer Cell 31:225-239(2017)

 

PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004

Pham L.V., Huang S.-J., Zhang H., Zhang J., Bell T., Zhou S.-H., Pogue E., Ding Z.-Y., Lam L., Westin J., Davis R.E., Young K.H., Medeiros L.J., Ford R.J. Jr., Nomie K., Zhang L., Wang M.

Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.

Clin. Cancer Res. 24:3967-3980(2018)