C6大鼠脑胶质瘤细胞

C6/C6细胞系/C6细胞株/C6大鼠神经胶质瘤细胞

Cell line name C6

Synonyms C-6; C 6; RGC-6; RGC6; RGc6

Accession CVCL_0194

Secondary accession CVCL_4060

Resource Identification Initiative To cite this cell line use: C6 (RRID:CVCL_0194)

Comments Doubling time: 14.75 hours (PubMed=2303324); 24-28 hours (DOI=10.5005/jp-journals-10082-02230); ~24 hours (CLS=500142); ~25-30 hours (DSMZ=ACC-550).

Transformant: ChEBI; CHEBI:50102; N-methyl-N-nitrosourea (NMU).

Omics: Deep quantitative proteome analysis.

Omics: Mitochondrial genome sequenced.

Derived from site: In situ; Brain; UBERON=UBERON_0000955.

Disease Rat malignant glioma (NCIt: C64069)

Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)

Breed/subspecies: Wistar Furth; RS=RS:0000982.

Hierarchy Children:

CVCL_ZB60 (C6 rho-0#14) CVCL_1970 (C6-BU-1) CVCL_6336 (C6-SF2)

CVCL_4V35 (C6/ACNU) CVCL_C9FG (C6/Cas9-hyg) CVCL_5657 (C6/lacZ)

CVCL_B7TS (C6rho0) CVCL_5H90 (C6TK-)

Sex of cell Male

Age at sampling Age unspecified

Category Cancer cell line

Publications

CLPUB00233

Lightbody J.

Establishment of differentiated clonal strains of glial brain cells in culture.

Fed. Proc. 27:720-720(1968)

 

PubMed=4873531; DOI=10.1126/science.161.3839.370

Benda P., Lightbody J., Sato G.H., Levine L., Sweet W.H.

Differentiated rat glial cell strain in tissue culture.

Science 161:370-371(1968)

 

DOI=10.1007/BF02618370

Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.

The animal cell culture collection.

In Vitro 5:1-16(1970)

 

PubMed=3468959

Yoshida T., Shimizu K., Ushio Y., Mogami H., Sakamoto Y.

Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma.

No To Shinkei 38:1065-1070(1986)

 

PubMed=2303323

Brauner T., Schmid A., Hulser D.F.

Tumor cell invasion and gap junctional communication. I. Normal and malignant cells confronted in monolayer cultures.

Invasion Metastasis 10:18-30(1990)

 

PubMed=2303324

Brauner T., Hulser D.F.

Tumor cell invasion and gap junctional communication. II. Normal and malignant cells confronted in multicell spheroids.

Invasion Metastasis 10:31-48(1990)

 

PubMed=19381449; DOI=10.1007/s11060-009-9875-7; PMCID=PMC2730996

Barth R.F., Kaur B.

Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas.

J. Neurooncol. 94:299-312(2009)

 

PubMed=25492533; DOI=10.3109/19401736.2014.982619

Gao J., Hu L., Peng H.-H., Shi J.-G.

The complete mitochondrial genome sequence of the rat C6 glioma cell line.

Mitochondrial DNA A. DNA Mapp. Seq. Anal. 27:2188-2189(2016)

 

DOI=10.5005/jp-journals-10082-02230

Kuduvalli S.S., Ramalakshmi O., Precilla S.D., Anitha T.S.

Evaluation of cell doubling time in C6 and Y79 cell lines based on seeding density.

SBV J. Basic Clin. Appl. Heatlh Sci. 2:146-149(2019)

 

PubMed=34917708; DOI=10.1016/j.dib.2021.107658; PMCID=PMC8666335

Silantyev A.S., Bukato O.N., Butenko I.O., Chernysheva A.A., Pobeguts O.V., Nosyrev A.E., Gurina O.I.

Proteomic dataset: profiling of glioma C6 and astrocytes rat cell lines before and after co-cultivation.

Data Brief 39:107658.1-107658.9(2021)