GT1-1小鼠垂体瘤细胞

GT1-1/GT1-1细胞系/GT1-1细胞株/GT1-1小鼠垂体瘤细胞

Cell line name GT1-1

Accession CVCL_6236

Secondary accession CVCL_8219

Resource Identification Initiative To cite this cell line use: GT1-1 (RRID:CVCL_6236)

Comments Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen.

Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).

Misspelling: GTI-1; Note=Occasionally.

Derived from site: In situ; Brain, hypothalamus; UBERON=UBERON_0001898.

Cell type: GnRH neuron; CL=CL_0011111.

Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)

Breed/subspecies: (C57BL/6J x BALB/cJ) F2 transgenic with rat Gnrh1 promoter-Tg(SV40).

Hierarchy Parent: CVCL_6235 (GT1)

Children:

CVCL_6267 (ScGT1)

Category Transformed cell line

Publications

PubMed=2196069; DOI=10.1016/0896-6273(90)90028-E

Mellon P.L., Windle J.J., Goldsmith P.C., Padula C.A., Roberts J.L., Weiner R.I.

Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis.

Neuron 5:1-10(1990)

 

PubMed=1714837; DOI=10.1210/endo-129-3-1584

Wetsel W.C., Mellon P.L., Weiner R.I., Negro-Vilar A.

Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons.

Endocrinology 129:1584-1595(1991)

 

PubMed=1542682; DOI=10.1073/pnas.89.5.1852; PMCID=PMC48551

Martinez de la Escalera G., Choi A.L., Weiner R.I.

Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: intrinsic properties of the GT1-1 GnRH neuronal cell line.

Proc. Natl. Acad. Sci. U.S.A. 89:1852-1855(1992)

 

PubMed=18406727; DOI=10.1016/1043-2760(95)00228-6

Wierman M.E., Fang Z.-Q., Kepa J.K.

GnRH gene expression in neuronal cell lines.

Trends Endocrinol. Metab. 7:60-65(1996)